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JADEO CBD and Wellness 2 weeks ago / Toronto, Ontario

#TrendingNow: CBD. How much do you know about it? Read now, to get all the juicy details. https://jadeo.co/SIG/CBD-and-Wellness/6-reasons-for-you-to-love-cbd

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4 Popular Trends in CBD Use

JADEO

4 Popular Trends in CBD Use

https://jadeo.co/SIG/CBD-and-Wellness/6-reasons-for-you...

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paddy CBD and Wellness 2 weeks ago / British Columbia

Everything you need to know about CBD, the cannabis elixir that doesn’t get you high As Pepsi and other major companies get into the CBD game, what exactly does it do? https://www.marketwatch.com/story/everything-you-need-to-know-about-cbd-the-cannabis-elixir-that-doesnt-get-you-high-2018-10-29

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Everything you need to know about CBD, the cannabis elixir that doesn't get you high

MarketWatch

As Pepsi and other major companies get into the CBD game, what exactly does it do?

https://www.marketwatch.com/story/everything-you-need-t...

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  • From Brianne Campbell

    Thanks for sharing! Ever since WADA took CBD off their list of banned substances, I had been wondering when the DEA would finally remove it from the list of Schedule 1 narcotics.

Michael Joseph CBD and Wellness 3 days ago / Hamilton , Ontario

How has CBD benefited your overall health and wellness?

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JADEO CBD and Wellness Toronto, Ontario

What are the top tips you'd give to someone who is shopping for a CBD tincture?

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JADEO Consumption and Safety 3 days ago / Toronto, Ontario


The Challenge of Accurate Dosing in THC and CBD

A great SPONSORED post by XANTHIC BIOPHARMA we found on http://www.visualcapitalist.co. We love the simplicity of this. The industry as a whole has a great deal of education to provide on why dosages are so individual, and that what works for one, may not work for another. (tm)

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vitalitycbd CBD and Wellness 1 week ago / Shawnigan Lake, British Columbia


5 Ways to Treat Depression Naturally

Depression can be difficult to treat, even with modern medicine and technology. However, there are natural remedies for depression that do not involve taking a pill every day.  Many medications for depression come with serious side effects that can affect everyday life for those who take them.  These five natural remedies can help you to find a solution to depression, without chemicals or side effects.  

1. Acupuncture. Scientists studying this ancient Chinese art say acupuncture can help alleviate the different symptoms of depression. In fact, the patients studied who used acupuncture as a treatment for depression saw results similar to those of patients who took medication.

In acupuncture, practitioners stimulate certain bodily functions by inserting thin needles into the skin at various spots that correlate with those functions. This practice is becoming increasingly recognized in Western medicine as a practical treatment option for several ailments, including depression. 

2. Therapy. There are often different therapy options available to those suffering from depression, a proven mechanism for healthy healing. Many teams can even create personalized treatment programs based on your wants and needs. A treatment program can be a great, natural way to regain focus in your life. 

If you are considering this option, start by looking for a therapist that you enjoy speaking to.  This could be the first therapist you schedule an appointment with or the fifth.  Once you find a therapist you can trust you can begin your path toward better health.

3. Meditation. Mindfulness meditation has been shown to help treat depression in several clinical studies. The practice is known to help lessen such symptoms as negative thinking and lack of focus. Doctors have concluded that meditation, when combined with therapy, can be an effective treatment plan.

This type of meditation is specifically aimed at thinking freely and not repressing thoughts. For those who experience depression in episodes, meditation has been shown to help prevent relapse. If you're interested in meditation, aim for two to three hours per week. Working the practice into your regular schedule is the best way to improve health. 

4. St. John's Wort.  This herbal supplement has been used for treating depression since the times of ancient Greece. It appears to be most effective when the depression is mild or moderate.  You should still check with a medical professional before taking this supplement, as it can react with other medications.

There are several parts of St. John's Wort that help to alleviate depression, though the most recognized is hypericin.  A typical dosage consists of 300 milligrams three times per day.  Some users suggest taking a full dose in the morning, as the herb can disturb sleep if taken at night.

5. Vitamin B.  Vitamin B is known for producing the brain chemicals serotonin, dopamine, and epinephrine, all of which impact your mood.  Something as simple as having low vitamin B levels can cause feelings of depression, fatigue, and more.  

For a diet rich in this vitamin, try to include foods like seafood, red meat, cheese, and eggs.  If you can't get enough vitamin B in your diet, your next step is to look at which supplements would work best for you.  Available over the counter in most markets and drug stores, these supplements are completely natural and come with no side effects if taken as directed. 

Medication doesn't have to be the only solution to depression. The aforementioned are just five of many natural remedies that have proved to be equally effective at fighting symptoms of depression without subjecting the patient to adverse side effects of chemicals. Another alternative option to naturally treat depression that has been gaining mass appeal and acceptance are CBD tinctures that are fortified with hemp derived cannabidiol. Cannabidiol or CBD is a non psychoactive derivative of the hemp plant that is also found in cannabis. 

- POSTED BY VITALITYCBD -

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vitalitycbd CBD and Wellness 1 week ago / Shawnigan Lake, British Columbia


Three Ways to Naturally Treat Eczema

Warm weather means one thing: it's time to shed those layers and bare some skin. However, if you happen to have eczema, the thought of showing skin may not feel so liberating. In fact, the thought might be daunting. So, instead of hiding behind your clothes, why not take charge of your eczema? You don't even have to run to the store and spend tons of money on fix-it creams. You can start by simply looking around your household. Here are three treatments for eczema that you probably already have on hand or around the home. 

Target the Inside

What you put inside of your body matters for what shows outside of your body. Making dietary changes is crucial for controlling eczema. Trigger foods such as dairy, fish, and gluten are considered to put eczema into overdrive. Avoiding these foods and increasing your intake of berries, green leafy vegetables, and Greek yogurt could help reduce future flare-ups.

Start on the Outside

Moisturizing the skin is of utmost importance for treating eczema, particularly during cold and dry weather. Many eczema sufferers find relief by applying certain oils, such as coconut oils, cbd oil and fermented cod liver oil, to the red dry patches on legs during a flare-up. If you don't have these items in the kitchen, both are easy to find in a grocery store. 

However, when eczema flares turn into sores, you can flip the script and use drying agents on the skin,  such as sea salt and Epsom salt. Be careful because direct application could irritate the skin even more. Mixing the salts with water and essential oils provides an effective salve, helping to heal sores while soothing the skin.

Keep It Clean and Simple

While medical professionals continue to explore what truly causes eczema, allergic reactions that send the immune system into overdrive, many dermatologists and other skin specialists suggest keeping it clean and simple. Cotton clothing and other breathable fabrics allow the skin to breathe. Ensuring what you wear is cleaned with gentle detergent helps as well.

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JADEO CBD and Wellness 2 weeks ago / Toronto, Ontario


[VIDEO] How Has Cannabis & CBD Affected The Life of This Medical Patient?

JADEO sat down with Maggie to talk to her about her double Cancer journey and the choices she is making to drive her wellness. 


If you are interested in learning more about cancer, please visit some of our other SIGs, namely Cancer or CBD and Wellness.

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The views and opinions expressed in this video are of the presenter and do not necessarily reflect the official policies or positions of JADEO.

JADEO makes no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability or suitability with respect to any content contained within the video.

JADEO urges you to consult with a qualified physician for consultation, diagnosis and/or treatment plans with respect to your medical condition(s) and/or wellness goals.

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Stay informed. Stay healthy. 
#WeAreJadeo


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Mike Robinson CBD and Wellness 2 weeks ago / Santa Barbara, Alberta


Cannabis Stops His Pain & Addiction After Near Deadly Wreck

By: Mike Robinson   "With a Reefer Madness Past, He Found Relief In The Magical Cannabis Plant"

It seems every day someone will share yet another success story with me in which they too have found some type of relief from Cannabis that their prescription medications simply would not give.  For some it’s migraines and body aches and for others it’s about stopping seizures, killing cancers, and so much more. The versatile cannabis plant has amazing abilities with it’s hundreds of components literally filled with many of natures essential oils, or terpenes, that have intensive healing powers. Many overlook these and tend to concentrate on the THC/CBD debates, others have reached a tad deeper down the Cannabinoid Medicine rabbit hole and found quite a few ways to give ourselves the relief we need.  Karen tells a story about her father, who she helped out and made sure he had treatment after a life threatening wreck.

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“I have witnessed the use of this magical plant change my fathers world. This isn’t a crazy story of how marijuana cured my dads incurable disease, but rather one of seeing a baby boomer come around to accept something he has been scared of his entire life! We had a “normal” upbringing, alcohol was around but never any drugs, not even marijuana.

“My dad was involved in a horrific vehicle accident that basically broke my father into pieces. The highway was shut down for hours and they needed the jaws of life to extract my father.  The other driver walked away with no injuries.   My Dad took the entire impact sustaining multiple life threatening injuries.  He was in the ICU unconscious for over 2 weeks, survived 13 surgeries and was a permanent resident of the hospital for 3 months.  He survived the surgeries, the physiotherapy and being away from home for so long.  He had some really terrible days, depression, another injury that isn’t visible to the naked eye. To say the least this was a terrible event for our family.  That was 2 years ago, he is now walking with a cane or walker, he has a terrible limp that he won’t be able to rid himself of, a painful memory of the accident.  He is now leading a fairly normal life considering he almost died and has been literally been put back together.  He is not half as functional as he used to be but we are grateful to still have him on the planet!”

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“Medications!  Dad was taking a cocktail of prescription drugs for months, the pain he experiences is unbearable and it hurts to see someone you love in so much pain.  When we brought dad home he had his blister packs of toxic pills to ingest daily to keep the pain at bay.  I have self medicated with cannabis for years, black market cannabis, not the best way to treat yourself but most of the time it worked for my back and neck pain and chasing the elusive sleep dragon.  Despite our attempts, Dad would not try cannabis, he is so terrified that he will have hallucinations etc.  He was raised as a farm boy and was warned of the dangers the “Devils’ Weed”, hallucinations, tripping out and losing control.  We convinced him to try some brownies I whipped up with a friends special butter, after a few tries he started to feel the benefits.  He felt relaxed, and that was enough to get him to explore further. With more encouragement from friends he eventually got a prescription from his doctor and starting taking CBD oil. He started talking to more people about it and did some research of his own, he now graduated to a CBD oil and a THC oil, treating inflammation, pain and helping with sleep.”
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“I have seen how much this plant has helped my dad, not only physically but also psychologically, he has gotten around the obstacle of fear and is now reaping the rewards. I know he will be using these products for the rest of his life and they will continue to make his life better!”

His story is similar to many – pharmaceuticals for pain mimic what cannabinoids can do but nowhere near as well. Doctors are still very uneducated in the world of Cannabis and fail to learn, even those that recommend cannabis to patients per the law are not tested at any level of knowledge because a doctor may not tell someone exactly how to use medical marijuana per a 9th district finding.   This is why many will give a ‘medical card’ to a patient, especially in the easier states, with less than 10 minutes sitting with them and basically not much of a clue of the history.

Mike Robinson,  Medicinal Cannabis Patient    Sr. VP,  MBX Research, Inc.

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JADEO Cancer 1 month ago / Toronto, Ontario


US Govt: Cannabinoids, THC & CBD Promote The Re-Emergence Of Apoptosis (the signal for a cell to die)

By: Mike Robinson
Medicinal Cannabis Patient and Director of Communications,
The American Academy of Cannabinoid Medicine

(Reprinted with permission by Mike Robinson as we here at JADEO just loved it!)

Cancer patients around the globe are looking to the internet for the most up to date way to treat life altering illnesses that will effect every single one of us on the planet in one way or another. As we read of GW Pharmaceuticals 'Epidolex' being approved by the FDA to treat seizures (CBD) - there's so much more to talk about than it's efficacy, side effects, and contraindications. We all know, or should, that there are known contraindications to every pharmaceutical and Epidolex has some downright scary ones that can and have caused 'status epilepticus' at an alarming rate (over 10% of trial patients). So be it, it's made it's way through the channels and will now become an item on pharmacy shelves. 

But what about Cancer? We've seen the posts about US Patent 6630507 which enraged the world and lit a fire under the movement for legalization of the plant globally, but what about United States Patent Application # 20130059018   Assignee: GW Pharma? 

A government that states there's no medicinal value in a plant doling out a patent on it to themselves and then to pharmaceutical companies abroad seems ludicrous but it's the reality we live in. Control of all by a few thousand elected officials over hundreds of millions is the way of the world nowadays in nations across the globe. God Bless America I guess would be applicable as we need a blessing after doing this to our own citizens!

Why haven't we heard more about this in the media and why are doctors yearning for information when it already exists? 

Probably because it was withheld from them while they attended medical school. As much as people in general would like to blame doctors for lack of knowledge in the cannabinoid medicine field, the problem is not with the physician or specialist - it's with a very broken system that hoped the Endocannabinoid System discovery over 2 decades ago by Professor Raphael Mechoulam of Israel would stay hidden away forever - so why teach it in colleges? In my current position I see the continual desire for clinicians and specialists around the world to learn more. The best teacher? A very well informed patient. The physician isn't fighting for their life so they're not spending 24/7 researching and playing around with different concoction or 'stews ala cannabinoids' as I call them! So it only makes sense that a patient that has a ton of time can learn much more about treating themselves (and others) as we're in this to stay alive vs. add it to our medical practice or be part of a sub specialty.

Let's take a look at what's been around for 5 years now - proof positive that Cannabis indeed will kill cancer cells and starve out tumors creating an impossibility for them to continue growing. Of course I could use scientific terms but those are a bit difficult for most to understand.

Federal Government Reports Marijuana Effective in Combatting Certain Cancers Reports ADSI (Global News wire Press Release 2013): LOS ANGELES, March 12, 2013 (GLOBE NEWSWIRE) -- The following is a statement by Advocates for the Disabled and Seriously Ill:

In a recent report, the National Cancer Institute (NCI), part of the Federal government's National Institutes of Health (NIH), stated that marijuana "inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines." The same report showed marijuana slows or stops the growth of certain lung cancer cells and suggested that marijuana may provide "risk reduction and treatment of colorectal cancer."

Referring to the NCI report, Patient Rights attorney Matthew Pappas said, "The Federal government's continuing attack on people prescribed medical cannabis by their doctors is hypocritical considering the benefits reported by its own National Cancer Institute." Pappas represents patients in defending their right to reasonably obtain medical marijuana. The patients contend the Federal government and various municipalities are trying to prevent them from obtaining cannabis for medical purposes in direct contravention of state laws. "Cities that ban dispensaries are denying patients the ability to obtain a medicine the Federal government's National Institutes of Health says fights cancer and they're doing it with the Obama Administration's help." Recently, the City of Los Angeles repealed its ban of medical marijuana collectives after Bill Rosendahl, a member of its city council diagnosed with cancer and prescribed medical marijuana said to fellow council members about the ban, "You want to kill me? You want to throw me under the bus?"

The NCI report also examined whether patients who smoke marijuana rather than ingesting it orally are exposed to a higher risk of lung and certain digestive system cancers. According to the government, 19 studies "failed to demonstrate statistically significant associations between marijuana inhalation and lung cancer." The report also identified a separate study of 611 lung cancer patients that showed marijuana was "not associated with an increased risk of lung cancer or other upper aerodigestive tract cancers and found no positive associations with any cancer type." In the area of prostate cancer, the NCI report was inconclusive and suggested further research was necessary. In its report, the National Cancer Institute also identified a "study of intratumoral injection of delta-9-THC in patients with recurrent glioblastoma" that showed tumor reduction in the test participants.

Despite the Federal government sanctioned and authorized NCI report, Pappas said Congress and the Obama Administration have continued to thwart marijuana research. In an announced effort to displace state medical marijuana laws, the Office of National Drug Control Policy described "medical" marijuana as a "myth" fueling "troubling misconceptions" in documents found on its website. The Federal government appears to be focused on creating more chemical drugs, many of which are the subject of various attorney television commercials seeking out those adversely impacted by those drugs. Pappas said both the Drug Enforcement Administration and the Office of National Drug Control Policy continue to assert marijuana lacks any medicinal value despite the research showing cannabis reduces certain cancer risks and inhibits the growth of tumor cells. He also commented that the Federal government's anti-marijuana position contributes to and encourages prejudice and public misconception about the legitimate use of medical cannabis as treatment for seriously ill patients.

In addition to anti-cancer properties, separate research reported marijuana appears to have "profound nerve-protective and brain-enhancing properties that could potentially treat many neurodegenerative disorders." In its report, the National Cancer Institute stated cannabis effectively treats insomnia and referenced a placebo-controlled study in cancer patients showing increased quality of sleep and relaxation in those treated with tetrahydrocannabinol, an active component in marijuana.

Responding to a White House statement that only a small percentage of patients prescribed medical cannabis under state laws use it to treat cancer, Pappas said "marijuana isn't just for cancer or AIDS patients – it can also treat, for example, sleeplessness." Although generally not a life threatening condition, Pappas referred to insomnia as a health issue regularly treated with prescription drugs zolpidem (brand name Ambien) and eszopiclone (brand name Lunesta). According to their manufacturers' websites, zolpidem and eszopiclone have been shown to cause severe side effects including aggressiveness, hallucinations, confusion, or suicidal thoughts. Pappas noted that, unlike those drugs, studies on insomnia similar to those reported by the National Cancer Institute show medical marijuana effectively treats insomnia at a far lower cost and with fewer side effects. Marijuana has also been prescribed for glaucoma, multiple sclerosis, chronic pain, and a variety of other physical and mental conditions.

Addressing the White House website statement that medical marijuana should remain criminally illegal under federal law, Pappas said that "with every drug, the doctor must consider the benefits versus any possible side effects. In its 3000-plus year history of medicinal use, there has never been a known, confirmed death caused by overdose of marijuana. To suggest that prescription drugs known to have severe negative side effects are alright and that marijuana can only be used for cancer or AIDS is nonsensical. It demonstrates how the Federal government's decision to usurp state sovereignty is harming people because burdening citizens with federal criminal records based on medical marijuana provided for under state law is simply wrong. To continue outlawing the use of a drug shown to have life-saving, anti-cancer benefits that has been used safely as a medication for thousands of years is irresponsible."

Jan., 2013 National Cancer Institute PDQ® report on cannabis:

www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page2

July, 2009 NIH report on cannabis reducing neck and head squamous cell carcinoma:

www.ncbi.nlm.nih.gov/pubmed/19638490

Nov., 2012 NIH report on cannabis breast cancer treatment:

www.ncbi.nlm.nih.gov/pubmed/22776349

Report on study showing smoked marijuana does not cause cancer:

www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729.html

Report on neuroprotective benefits of marijuana:

www.foxnews.com/health/2012/03/20/researchers-study-neuroprotective-properties-in-cannabis/

White House "Fact Sheet" on Marijuana Legalization:

http://www.whitehouse.gov/sites/default/files/ondcp/Fact_Sheets/marijuana_legalization_fact_sheet_3-3-11.pdf

Office of National Drug Control Policy documents:

www.whitehouse.gov/sites/default/files/page/files/marijuana_fact_sheet_3-28-12.pdf and

www.whitehouse.gov/sites/default/files/ondcp/issues-content/medical_marijuana_information_packet.pdf

When we review this information it's beyond disturbing, but to stay disturbed would be a waste of time we literally do not have - especially if we're fighting cancer which half of us are or have already. Those numbers will only increase as the environment of harm we all live within changes by the day and not for the better. As plastic fills our oceans that are already flooded with waste from Nuclear Power and more we all know our time on this planet is limited. The type of crimes against humanity that are being perpetuated by the day across the globe by nations starving their citizens from a plant that heals are preposterous - but they are the reality. Lawsuits seem fruitless, even the WHO's demands regarding CBD are going unanswered in regards to the wish for 100% removal from all nations controlled substances list. Baby steps need to be leaps and bounds as we are destructing the most valuable resource known to mankind - people.




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  • From Janelle Simone

    This article was extremely insightful!

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Fighting Epilepsy and Cancer with Cannabis

The Fight Against Seizure Triggers Persists. Controlling Them With Cancer Is A Unique Battle:

One of the biggest questions I get asked after five years of using Cannabis to stop the seizures and so much more is “Mike, how do you do it and what do you use?” That’s a very tricky question to answer for two reasons. There’s multiple types of Epilepsy and Cancers as well, so I wouldn’t want to infer that whatever I’ve done would work for another as there’s billions of human beings on this planet with individual metabolisms and physiology so everything works differently on everybody. That’s the basic philosophy used. I also use so many different delivery methods especially for Epilepsy – but that statement gains more attention and will immediately bring up another question “What is a delivery method”. Let’s go through some of the common questions that are asked and I’ll give you my version of the answer.  By far this is not limited to Epilepsy as treating multiple health problems successfully with Cannabis is how I stay alive.  My hopes are that someday everyone has access to the plant and it’s incredible healing powers – until then let’s learn together!

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I am no ordained ‘expert’ in my opinion – I’m just a patient like you that’s gained a different type of perspective by having involvement in the past with large compassion programs and over the past year as the Director of Communications and more for the American Academy of Cannabinoid Medicine. I work around "experts" and with them, but we don’t see eye to eye on everything as I believe patients have outgrown doctors in knowledge on how to dose and use cannabis. Nowadays the experts generally DO NOT have M.D. behind their name. My own exposure to the 'experts' in Cannabis so far has been a massive let down, But, doctors have started to learn more and there are a few experts that know so much about the body and the Endocannabinoid system but seem to not understand many of us that have theories regarding the difference in human physiology – the fact that we’re not universal creatures. This, I believe, is why Rx medications have failed in an ugly way for the most part. Now don’t get me wrong, many people also stay alive due to the modern treatments or pharmaceuticals.  Others, however, will perish to overdose, serious side effects, with cancer the known possibility of death due to the type of ‘modern treatment’ – or like I was and am – ill due to the simple lack of plant medicine properly delivered to my body over a period of time. I’ve used cannabis for decades but I’ve only used it right, as an effective treatment,  for 5 years. And that meant ingestion of the plant in one way or another.

Now I've stated the Global Cannabinoid Research Center, an educational entity just created to provide whats needed for Collegiate Academics. Of course this is also what's needed by the Clinicians and 'Specialists' of the world that are not too involved in Cannabis and need continued medical education. Recently, I presented on CBN and the 4th World Congress on Cancer Medicine in Moscow, Russia.  Next year I'll be doing a workshop on Cannabinoid Medicine in Tokyo, Japan at the 6th World Congress on Cancer Medicine and Survivorship and holding a 3 hour educational seminar for the thousands of doctors and scientists that attend. As well they've passed on the honor of being an Organization Chair Person, or in other words the small group that oversees the entire event as specialists in our field. 

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While fighting my own battles and assisting others, it’s always been inspiring to watch the kids that fight so hard. Whenever times got rough and alone I’d be picking myself up off the floor or lying in a hospital bed after the fact, whether in ER or already admitted, thinking of the kids that didn’t know what was happening to them always made me toughen up.  Now I have Genevieve with me daily as a hero that fights seizures – and with the plant as her armor. If she can do it,  so can I and we both rely on the same thing – the Cannabis plant and our loving family. As we both are fighting the same thing in essence,  Severe Refractory or Intractable Epilepsy, the type of protocol is somewhat the same. Minus inhalation for her of course. I’ve found that I’m not alone – other adults that are doing well with various types of Epilepsy are using both ingestion and inhalation as well. I’ll go deeper into that as it seems to be a very intense subject that many ask about quite often.  With kids we keep it to ingestion as long as possible and try the most subtle approaches unless otherwise is indicated, such as with our Genbug

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Q. What is a Delivery Method? 

It’s how you use Cannabis. Some will smoke or vaporize the actual flower from the plant, and others will vaporize (using vape pens often with replaceable/refillable cartridges). Some vaporize by ‘dabbing’ of concentrates of THC, CBD, or even both as I do. The most medicinal way in my opinion is through digestion of oils that have concentrated amounts of Cannabinoids. THCA, THC, CBD, CBN, CBC, CBG – so many different cannabinoids we know of and many others we don’t – all in this amazing plant that we can literally eat raw or take in oils and more. There’s also salves and other products for the skin including anti aging that I’m not including in the ‘inhale/ingest’ discussion. Through the years there was even a Tea created and the name coined after my love of purple! There’s suppositories,  trans-dermal patches, chewing gum, edibles of all types – the list goes on and on. But, if you stop and think about it much of this can be divided into two types of delivery.  Internal via digestion or by Inhalation. All deliveries have a different effect. The biggest being that inhaling higher THC cannabis either by smoke, extracted oil vapor, or concentrated dab vapor – the same thing happens. Signaling occurs in the brain with a bit hitting the body.

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Q: What’s the difference between smoking or vaping and ingestion?

Quite simply the inhalation method tends to gain the attention of Cannabinoid Receptors located in the brain which is why the user gets a fast ‘head rush’ from THC and other activated cannabinoids that cause this as discussed. The length of time the person is ‘medicated’ is much shorter with inhaling than via digestion.  I use inhalation to give me immediate relief from anxiety and other symptoms (aura types) that are associated with the triggers of Epilepsy. By inhaling a strong THC concentrate I find that I am immediately medicated much more than any Rx rescue medicine, but others prefer a different delivery for the exact same feeling of relief whether from anxiety, pain, or other health issues. So many in our society have slowly changed their position about people that smoke ‘weed’ ‘pot’ ‘marijuana’ – there’s so many names for Cannabis it’s incredible. Ingestion on the other hand tends to activate the entire body’s receptors creating a much more intense medicine. Instead of hitting only half of the receptors of the Endocannabinoid System ingestion of a full spectrum THC plus other cannabinoid infusion will hit all of the receptors.  I may not be seizing radically by the day, but certainly feel like I might at times. Now some have reported the Cannabis CBD or that which comes from buds to be working extremely well – I’m one of them as I use it for all of us in the family. I don’t have quite the same luck with isolated CBD, but others report that it helps them. I’m looking for control of a radical type of Epilepsy and Cancer as well. We treat multiple ailments from Autism, Anxiety, and Arthritis in the A column alone, one plant to replace multiple medicines.

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Some  professionals in the industry prefer Cannabis and Hemp be the terms used. Most dislike the word Marijuana but others simply don’t care. I know multiple older cannabis experts that still call it dope! The decades of terminology that seems to stay put with those that have been using it far longer than those that have been looking to profit from it I believe are here to stay despite the desires of many. But lets get onto healing with the plant, that’s what truly matters! Inhaled Cannabis is the term I’ll use as I don’t care about the politics of the words, I care about people learning how to stop seizing and feeling better from whatever the health issue is. The world doesn’t realize what we go through.  The amount of anxiety, loneliness, and depression people with Epilepsy and other illnesses have is internalized and bears an incredible weight upon the person. With Epilepsy – over 50,000 people perish annually, often in their sleep. Some of my online friends will check in with a simple message “I made it” in regards to living through the night. Many can’t imagine that fear as they do not live with a label known to take lives with zero notice.  In our world we’re very aware that one of the top neurological disorders in America is at the bottom of the list for funding of research. Now let’s talk about ingestion of cannabis to rid us of these problems!

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Q: Mike, why do you like ingestion and inhalation both? 

Wow, that’s got to be one of the top questions I’m asked as well. When you ingest cannabis in it’s various forms it does much more than hit your brain’s main endocannabinoid system and the receptors within the cerebral cortex, instead you’re looking at exciting or activating ones that are located throughout the body and concentrated in the CNS and immune system – literally hitting all of it’s receptors vs half of them.  So when I ingest oils they move throughout my internal organs and treat me from the inside out. Since I’m also fighting Cancer, this is imperative. I also use topicals at times, cannabis infused in oils put directly on the skin which I don’t include in the inhalation/ingestion topic.  Even if I wasn’t in a cancer recurrence I’d still be using some infused oils daily as the combo of both inhalation (for me I like vaporization but also smoke) and ingestion is the key for both myself and Genevieve. Without ingestion of oils I know neither of us would be doing this well. I know it keeps me alive. As an adult inhaling it, I believe in my own theory, it activates the entire system by making what we’ve ingested come to life in a whole different way – much more medicinal and much more value by combining these intake methods.

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It also takes the people that surround you to be aware of what you need and to be responsive for you. Without the team we have here it would have been beyond difficult to battle the problems that still face both of us. Both Gen and I still have Epilepsy regardless of seizure control. We both ingest quite a bit of infused MCT to gain the cannabinoids we need along with the ketogenic ability of the base oil itself.  So whatever you are using make sure you’re eating some of it or ingesting – it’s a must. Also make sure your ‘team’ is aware of what you use and whatever Rx medication you still take. Without a quick response from Mom both of us would be subject to what a trigger can do. I like the fact that infused MCT can easily be used as a rescue – it takes 4-5 ml but that’s not much and it’s great for the health. One thing we always aim to do is rescue before a problem occurs, and it works.  With a ton of autoimmune difficulties some medications have caused side effects that trigger a neuro response. Thankfully Genevieve and I have a team from the youngest to oldest in the family that are all knowledgeable on our specific needs.

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Back to digestion and inhalation – I need both to do the job. I’ve found many times that both used simultaneously, literally eat some infused MCT or Olive Oil, and then dab or smoke as it’s melting in my mouth. seriously does the trick and can last for many hours. I call it the double whammy and it stops any feeling that is associated with Epilepsy, Anxiety, PTSD – even depression and symptoms of these neuropsych often situational multi diagnostics are within just about every illness imaginable. Sometimes I’ll use a stronger Super critical CO2 extraction that’s been turned to ‘THC Distillate’  if its needed. I continue to use various products as I’ve found there’s few others I can talk to (sometimes nobody else) that’s recovered from the same diagnosis – Severe Refractory Generalized Epilepsy and has found a way to manage it with Cannabinoids. Finding others that have it documented in medical records is even harder. One thing I do see too often nowadays are claims by people that are ‘seizure free’ – we don’t know if that’s the case if an EEG isn’t connected to us. Sometimes I see it along with an ad for a product – nowadays I’m very leery of this.  I try not to associate myself with products at this time as I’m not a walking ad for anything but the plant. Maybe that will change, for now – I’ll stay a patient. After all, there is a huge industry out there and people will do quite a bit to sell products, although I find that this is limited and most have good intentions. Let’s get back to nature and I’ll try not to get off track!

Back to the battle for independence and wellness. For me,  it takes changing the strains and how I intake it.  Many get hung up on what strain and ratio to use. I literally don’t care as long as it’s clean cannabis and it’s got the terpenes and more intact as well as fitting the purpose. For example I’m not looking for a straight sativa or dominant hybrid alone but will mix it with Indica to make a nice mix. I don’t go off of ‘keep it the same’ – I go off of ‘change it up’. Why? Because keeping it the same has proven to not work unless the same is of a quality I don’t see on the market but would love to see created and available for everyone – that would take a change in federal law.  Anyway, after awhile it’s became intuition in deciding what to use or even make – I literally know my body and what/when it needs. My EEG may be clear but I still have problems at times. When I ingest infused oils they are lower in THC and are subtle, if it is a full extract thick black oil for example it’s much more intense and high in THC – definitely can cause a bit of a medicated feeling like inhalation does. I prefer to infuse MCT coconut, olive, and other oils infused with cannabis vs. using the strong RSO types as there’s multiple issues with both the long term use of oils prepared with solvents and whether or not the oil is clean.

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Dr. Alan Schreiber is a farmer and researcher in Eastern Washington where he grows a variety of crops including marijuana. (Photo by Rajah Bose) He’s also known for having expert extraction on site with the cleanest of oils.

Stopping severe refractory seizures that can and do kill means sometimes you may have a partial onset – or the start of one. This comes with panic and so much more – those of you with Epilepsy or any health issue associated with panic know exactly what I’m speaking of. Sure, the neurologists can’t find a trace of it in the short EEG tests they do on me –  there’s enough cannabinoids in me to literally beat it. “Great job” I might tell myself, but still  Epilepsy will forever be part of life and the “Purple Family” of Epilepsy Warriors and parents I adore come with that – must say I don’t mind that part at all!   Regardless of our diagnosis, illness, or struggle  – we’re all in this whole Cannabis fight together. But more importantly we’re all on this earth together to help each other.  We do this by gaining knowledge of people’s specific needs and carrying out acts of courage nowadays that I call kindness. We live in a brutal world, that can’t stop any of us from spreading the word of how we treat our problems with Cannabis or how we should be loving each other.

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Does Cannabis stop the seizures for me? YES.  How? By interrupting the interrupted signals in my brain and redirecting them to where they should be going. That’s the simple way to explain what I’ve learned via treating myself, others, and extensive research. Sure I could quote studies and so much more, but I’ve found many of them to be highly objectionable. How could the application of cannabinoids or cannabis on me be compared to a rat, mouse, kangaroo, or even a small group of other people? We’re all unique. Some people respond really well to CBD. I did at first with vape pens and ingestion of it coupled with ingestion of raw cannabis. That’s literally how I stopped seizing why I look at both of the basic delivery methods as the way to go. At first CBD alone and ingestion of raw Cannabis was the trick to gain full control but I found that changing what you use or your ‘protocol’ is imperative at times.

A good friend with Epilepsy came and saw me and we discussed this. A person that never inhaled before started doing so with very small amounts along with a THC/CBD combo infusion of oils. Guess what? It also worked for her – another adult with Epilepsy that had serious seizures interrupting life is now experiencing the ‘Awakening’ as I call it. It’s when a person stops seizing and starts remembering life and past events.  Medicated on Cannabis is how I remembered all of the past that I had forgotten due to a 1995 high speed auto racing wreck.  For others the exact same thing happens, if indeed, they stop a severe seizure pattern. It’s an incredible feeling. Much like going into remission using cannabis – and I’m not talking cancer. It could be addiction, alcoholism, Lupus, Lyme’s, Pain Management or literally any health issue that’s overcame and causes a person to have a renewed life based on the use of Cannabis.

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When I first gained control over severe back-to-back grand mal seizures in 2013 the awakening was incredible. It almost scared me and still does some days. Having a life again means that people are no longer going to be watching over you as they did when you had Epilepsy that was very active. With any health issue that has others on edge one gets in a pattern, and that pattern is indicative of reliance on others vs. yourself. Suddenly the reliance on others ends because no longer are you ill. Boo-hoo so one would say – You’re free! But, that’s why I wanted to write this blog! Even today as I use multiple strains and multiple products I still have this edge to me at times, I do right now as I’m typing. On edge, hard to explain but easy with others that have Epilepsy for some reason as most know exactly what I’m talking about.  The only difference is my likelihood of a seizure is probably 95+% less than others feeling this way only due to Cannabis. A partial onset or a brief stare off absence could happen and does with no notice of it by any other – the EEG still comes back negative.

A neurologist wants to do a 7 day study of me in the hospital and ‘turn his eye’ at the cannabis oils I use while hooked up to the machines. “Why would I possibly want to do that” I asked him in his office. His response “To see what happens, I’m curious and the insurance company approved it.” Wow, so the insurance company approved a $30,000 hospital stay but doesn’t pay for the medicinal cannabis I use that works.  This is the world we live in.  I denied his request to use me as a test tube rat and let him know I’ll continue to go with what causes that EEG to be negative!

Going through the last 5 years of doctors hasn’t been simple. Sometimes I’ve had to demand to either notate Cannabis Oils and CBD oils by milligrams per day as medicines on the list of medication – or I find another doctor and did over a half dozen times, hasn’t been simple. Intimidation is no longer an issue in doctor appointments most of the time – and that doesn’t bother me, it’s the mannerism of many physicians that do. We are people, not to be processed through a facility but to be cared for. Much of that has been lost in what was once doctors that practiced medicine and is now a medical industry. People are treated poorly because they choose to inhale Cannabis instead of ingest pills. The facts are simple, statistics are showing 25% on upwards of close to 50% of pain patients either moving over to cannabis in full or in a huge part. No longer wanting to consume Rx drugs that they know kill. I should know…  I am one of them.

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This is why when I discovered that both inhalation and ingestion was the key I went for it full force and have not stopped. Infusion of oils is very simple. Many people make Cannabis Budder (butter),  instead they could be using MCT coconut oil and keeping the temperature at or below 220 to not break the ‘chains’ of the Medium Chain Triglyceride Coconut oil. Of course many would argue they want their budder to make edibles with! So be it, I just made some myself!  Infusing Cannabis into natures oils has proven to be simple and super effective – especially using higher quality Cannabis material. MCT oil is a bit more temperamental than others but has so many health benefits. Olive oil is not so sensitive and various temperatures can be used to activate the plant.  I look at it simply.  I don’t want to have long term ingestion of any oil that could possibly have solvent in it,  but will do so short term as long as I have the labs that say it’s clean since It’s a Cancer battle along with Epilepsy once again.  So, to wrap this part up, fighting severe refractory generalized epilepsy with Cancer is very much different than fighting partial onset seizures or complex partials. Many aren’t aware that there are over 40 different types of seizures and countless types of Epilepsy diagnostics.  There’s 1/3rd of us roughly that don’t respond to medications, for me 27 different pharmaceuticals were tried over an 18 yr. period and when I started using oils I was on 12 medications/48 pills a day for Epilepsy.  That’s been narrowed down to one specific Rx for Epilepsy now with 4 tabs along with my various delivery methods of cannabinoids of all types.

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My motto?  Don’t discriminate against any one cannabinoid, it’s unfair as they all have functions far beyond knowledge already gained. We, the people with Epilepsy and other health issues, have lives that sometimes cause us to stay shut in.  Sensory overload, I compare it to what I’ve seen through the years with Autistic children, including my own. Having a neurological problem like this means that we have to watch for all kinds of things.  Being careful about that lighter flickering in the dark if I’m smoking a bong load is crucial to this day, I don’t know if it’s the anxiety or a tad of PTSD over being intubated and put into ICU over 3 dozen times due to status epilepticus that could not be stopped (non stop grand mal seizures that require the patient to be put into a drug induced very temporary coma generally with propofol).  Either way, our lives are effected in a brutal manner.  Many of my adult friends are a bit bewildered at the fact the FDA is about to approve a CBD only drug that supposed to be a natural extract but they will not be allowed to get it, even if they have a similar diagnosis as I do.

Limited FDA approvals for ‘cannabis drugs’ that are easily obtained throughout the US already seem a bit ridiculous. I feel bad for my friends in other states I can’t help due to strict laws. It’s a feeling inside that keeps a humble attitude intact. I hope, pray, and wish that every last person gets the ability to be nervous about seizures because they simply aren’t having them like they used to.  I hope that all of my friends suffer social anxiety standing in long lines waiting to take Amtrak trains across the country – alone!!! What I wish for? Independence for all – so what – we deal with anxiety like everyone else, it’s just new for us. It’s not different than anyone else in any other situation that now has freedom – it’s a whole new world so make the best of it.  Everyone is battling something,  always be mindful of this.

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That’s how I fight Epilepsy with Cannabis. I keep on persisting until I find ways to make the very best of what’s happening regardless of whatever obstacle or hurdle there is to leap over. I searched and finally found a doctor that would keep all records from all other doctors so I could document the last five years in a combined medical record. I found an expert in Cannabis right in my own town and eventually went to work to help the whole legitimization of our medication as a volunteer at first. We all must look to our doctors and ask them a simple question “Are you certified in Cannabinoid Medicine?” This should be our line of question and approach to a doctor vs “Is it okay for me to try CBD or Cannabis oil?”  I had to take control. Sure, this meant I lost some doctors at first but soon after I let them know up front and as well found a way to get the oils on my chart,  it became easy.  Nurses are always an excellent resource as they’ll ask you a valuable question ‘Have you started any new medications or changed any doses’?  What an excellent opening…

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This the time to state ‘yes, I’m using a CBD oil supplement at 50mg a day’.  Or whatever you may be doing – I used ‘I’m using CBD supplement at 100mg day and C.O. at 500mg’.  The Nurse writes it onto the medicine list in pen at that time then a receptionist or administrative assistant does the data entry.  One doctor questioned me about this 3 months after I first had it listed! Now that was an interesting conversation as she sat in there and vividly listened to how Cannabis oils had changed my life. If I had this link back then I would have shared it, I hope patients will encourage their doctors to learn. Here’s a link to the The American Academy of Cannabinoid Medicine that may help them learn.    http://www.aacmsite.org

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Doctors don’t have to be without knowledge and patients don’t have to feel like they’re under the gun when trying to talk to their physician about how to treat Epilepsy or any health condition with Cannabis.  Don’t expect a huge nod to go forward and a bunch of advice, you’d have to find one of the few specialists out there that knows this information – if your insurance covered it or if you could afford the visit.  This is why we all have to take our medical problems into our own hands as much as we possibly can. There are uses for western (modern) medicine and there are also disasters that can occur due to it in my opinion – especially when a patient starts to take pills due to side effects from pills. I’d rather take a different cannabinoid (CBD) to offset the feeling of others (THC,CBN) if necessary or combine them all and gain the very best medicine I can from the plant.

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Fighting Epilepsy with cannabis is always a unique battle. Keep that in mind when you see universal dosing and advice given. The same goes for almost every other medical problem cannabinoid medicine is used to treat. Always keep in mind the large number of types of diagnostics and types of seizure disorders – it’s just like cancer. There’s nearly 100 or more drugs for Epilepsy because of the vast spectrum of the diagnosis.



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Mike Robinson, Medicinal Cannabis Patient, Santa Barbara CA.

Founder, Global Cannabinoid Research Center, Cannabinoid Education for all 

Related comments

  • From trevmorones

    Your strength is admirable. Thank you for sharing, inspiring, and educating.

  • From Connor Christine

    Thank you for sharing. You are an inspiration.

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Prescription Drugs & Side Effects: Is It Worth The Risk?

We all know that pharmaceuticals can save lives, but we also know they kill. But exactly how many? The numbers are beyond shocking.

Reading Alex Steblowsky’s  Facbook post can be rather interesting – especially with my background in not only taking a plethora of prescription drugs and gaining multiple cancers thereafter, but in my research in regards to that being a large part of the reason why.  Let’s take a look at what Alex has to say…

“New Harvard study reveals institutional corruption of pharmaceuticals & how the FDA cannot be trusted with public safety.  According to Harvard report, in US alone, every week, 53,000 end up in hospitals & 2,400 die as a result of taking prescription drugs as prescribed.”
http://seattleorganicrestaurants.com/vegan-whole-food/institutional-corruption-of-pharmaceuticals-how-FDA-cannot-be-trusted-with-public-safety.php

Shocking to say the least! I can’t count the number of past and current Cannabis patients I know that have illnesses related to or directly from taking pharmaceuticals and now must take even more pharmaceuticals to offset reactions and side effects.. Many have turned to the beautiful cannabis plant for medicine instead – slowly working away from everything from pain medication to seizure medication for those that find control and help with cannabis vs. pharmaceuticals.
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Let’s learn more from Alex:
“Total corruption: Drug companies bought their way onto FDA advisory panels
It is now an undeniable fact that the pharmaceutical industry weaseled its way onto key U.S. Food and Drug Administration (FDA) advisory panels, which were instrumental in shaping the way drugs are safety tested and approved. According to The Washington Post (WP), a recent public records request has revealed that drug companies purchased special access onto these panels, where they were given the keys to the kingdom in swaying decision-makers about official drug policy.”
http://www.naturalnews.com/042562_total_corruption_drug_companies_FDA_advisory_panels.html

And by far it does not end with this…. Alex informs the public on a daily basis. It’s people like him that continue to walk their talk that change this world. Like the saying goes “I can’t help everybody, but everyone can help somebody”….

“The FDA continues to be one of the most dangerous government agencies in the United States. The sheer scope of people it affects with its corruption is staggering.  Constitutional Attorney on US Federal Drug Administration (FDA) Corruption, Disinformation and Cover Up of Health Dangers”
http://www.globalresearch.ca/constitutional-attorney-on-us-federal-drug-administration-fda-corruption-disinformation-and-cover-up-of-health-dangers/5430348

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We all know these drugs are dangerous. The FDA requires TV and Radio ad’s to blare out the side effects which are a very true reality for many.  Those that say these drugs are ‘safe’ obviously have not had permanent brain damage or died or they wouldn’t be able to make such a ridiculous statement in  this day and age of people that are now ‘awake’ about the dangers of Big Pharma and doctors that simply do not take the time to check contraindications – drugs that should not be taken together.  When a medicinal cannabis patient walks in the doors many times the physician will tell them they don’t know enough about the plant or there’s not enough research.  That same doctor that was trained in medicine for how many years…. fails to check and see if he or she has prescribed a medication that will mix poorly or interact with Cannabis. So why would a doctor make any statements about the pharmaceuticals being ‘safe’ when their actions as a doctor simply are not.  People die, it’s no joke and it’s people like Alex that are trying to educate the world.
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In a recent post Alex went on…

“It is steadily coming to light that we have for some time been the unwitting victims of a massive fraud by Big Pharma and psychiatry, the money-grubbing, brain-damaging Axis of Evil.

We have not just been sold snake oil or “miracle cures” by charlatans. We have been sold snake oil that not only doesn’t cure anything but also causes profound harm to anyone duped into consuming it.

Same thing with doctor’s, it’s all about the money not your health.”

Enough said, we know where Alex stands, and I am with him.
Visit his Facebook page at: https://www.facebook.com/asteblowsky?tn-str=*F

Thank you Alex for making my point even more clear about the Cannabis plant. It’s the reason why I’m alive and millions more. Mainstream medicine has plenty of room to integrate it into the use of other medications.  With Cannabis, as a researcher,  I’ve learned that we can utilize medications that exist in many different ways safely.  Many are simply unsafe and need to be removed and destroyed or put into schedule 1 where Cannabis should be taken out of it for obvious reasons. While the world revels at prescription CBD being made available soon, many in the know are aware it carries the same scary side effects and has killed already.

No drugs are free of side effect or completely safe… but we have alternatives that are pretty close, and in my opinion very perfect replacements.  Pretty ones too!
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Mike Robinson,  Medicinal Cannabis Patient,  Founder, The Global Cannabinoid Research Center

Related comments

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


The Cannabis Love Story: How Genevieve Created A Family

A Child With Severe Autism, Epilepsy, & OCD Sculpted Her Own New World Filled With Love;

When I first encountered Anne Mari, Genevieve’s mom, it was by mere chance. In preparation of a long trip to see Compassion patients using cannabis oil the following morning, a cell notification grabbed my attention. Both phones normally have sound turned off -directing a Compassion Alliance providing and re-gifting CBD/Cannabis Oil means both of those phones are continually busy, to this day I still don’t know why I had sound on that night. I peered at the message: “I’m desperately in need of help for my 13-year-old daughter. A friend gave me some CBD and I don’t know how to use it. She has severe Autism and seizes most of the day. Now she can’t go to school anymore without UCLA clearance.” How could I not respond, after all I saw it come through. Little did we know Genbug was about to create the family she always wanted. Our fate was ahead of us as our lives were about to beautifully unite.

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When you spend a few decades representing kids in special education administrative law issues, you become accustomed to getting urgent messages. In the world of Medicinal Cannabis, those messages strike me quite a different way as I know that many times it’s life or death. 50,000 people per year die to seizures in the U.S. alone. That may sound dramatic, but it’s a fact. Simply put, not all patients live to tell stories of success. Genevieve’s is not only one of success, but one of love. With Severe Autism, Epilepsy, and ODC,  her life had became extremely sheltered.  It created a world in which she could be her own worst enemy to her skin. Excessive ‘digging’ requires her to wear gloves day and night. Before Cannabis Oil she held her iPad as she gazed. Didn’t walk through the house well and was seizing over 25 times daily with deadly grand mal seizures.  Definitely this created a life for her mom and sisters that surrounded Gens needs, it had to. Due to the severity of her diagnosis everyone had to give up a little to make sure she got the most.  Add to that a tragedy – a decade ago her father passed. Nobody knew that Genevieve, in her own world,  wanted Daddy.

From the moment I met Anne Mari and Genevieve there was a feeling of urgency to their situation like one I’ve never felt before.  With so many children involved in a compassion program it was at times difficult to keep up back then.  But Genbug had an advantage as her mom had started dating. After a few months of this I got a text from Anne Mari: “She’s asking for you, we (older sister Fatima and her) clearly hear her saying ‘Daddy’ as she points to your photo”.  And then I heard it myself and my heart melted.  Genevieve, without a doubt had plans. The next time I saw her she was watching a Simpsons video on her iPad and pointed to Homer, the Dad. Then she pointed at me “Daddy”. Wow, who would have guessed just a year and a half later we would be a happy family – all created by her! One day, during a trip that including stopping at Anne Mari’s and Genevieve’s, I had an odd feeling that I belonged where I was. Personally it sort of made me freak out as I’ve traveled around for years and being stabilized in a home with my own family didn’t seem like a reality.

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(She used to want to cover her eyes with mommy’s sunglasses, now she stares right into my eyes so deep it penetrates – kids with Autism will often avoid eye contact)

Anyway, back to how we met! I responded the night Anne Mari texted and found she was located right on the way to where I was headed the next day. When I got to her home, I knocked on the door and the response was frantic – Genevieve was on the floor seizing. She went into what is called status epilepticus or back to back grand mal seizures. Beyond dangerous – this is how life is lost to Epilepsy. Quickly she was administered Cannabis Oil. The CBD that mom had been strong vape cartridge oil was too high in CBD for easy dosing for a new patient and frankly, wasn’t my preference for the situation. I had my own and used it. Consequences ran through my head but not about using my oil for the child at all.  Having Epilepsy myself I’m all too aware of the damage seizures cause – and with kids like her it furthers any developmental delay to have continued seizures.

Quickly the seizures slowed and we started going over her history. As usual a plethora of medication was prescribed to her, some of them for side effects from medication itself. Pro convulsive medications are often given to children with Autism for behavior before a doctor checks for Epilepsy. Since 1/3rd of children with Autism will have Epilepsy that’s not the wisest move in my personal opinion, of course I can’t give medical advice. Without a doubt Genevieve was on a cocktail of medication that would cause seizures and seizure medication that she was allergic to. One medication caused her to get overwhelmingly energetic and the next would put her into a daze.  None of it made sense and thankfully her doctor agreed to make a big change the next day. I stayed the night in town so I could come back and see her the next day. Mom Anne Mari told me on that 2nd day, “I felt like I lost my daughter, like she had been kidnapped” Anne Mari told me at first  “Days of seizing turned to weeks than months. She did well for a few years and then medications were changed again.” I explained my own battle against Severe Epilepsy and more using Cannabis oil with Anne Mari as she brought Genevieve out to see me, now using her iPad and telling me “I feel happy” on it.  As she made her way back to her room without wobbling this time as I saw her do the day before, I heard a humming sound. As I looked to Anne Mari it seemed as if a river of tears fell “That’s her happy sound, I haven’t heard that in so long.” 

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(Genevieve happy once again)

Both of us have Refractory/Intractable type – no Rx medications are known to keep seizure control. Because of this prescription medications haven’t worked for Gen or I, instead causing complications. Cannabis oils have been the answer. From CBD to full spectrum or extract oils, it’s been what’s worked. “She had a bad allergic reaction to seizure medication and ended up in the hospital.” mom, my fiance now, told me. I looked at her medication and the hospital discharge papers from the Rx medication severe side effects. Then I noticed it was not discontinued! The Neurologist had told mom to keep on giving her what had just landed her in NICU. You can read the whole story of how Genevieve responded to the compassion program cannabis oils here:   https://www.linkedin.com/pulse/hours-after-first-dose-13-year-old-girl-severe-autism/

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After the positive reaction to Cannabis Oil in stopping her seizure and literally stabilizing Gen overnight, Anne Mari then asked me to represent her to get her back in school. Together we worked quickly to get the doctors to see how fast CBD and Cannabis Oil worked. It was literally only 48 hours and she was back! We continued to work together and yet another LinkedIn Pulse article was written about how Genevieve was quickly recovering from Severe Epilepsy and was suddenly making leaps and bounds towards socializing and trying to talk. Her initial recovery was such an intense one that doctors were amazed, even a neurologist who wasn’t on board at all in the beginning was forced to change his mind. “What has she been taking, have the medications been working” He asked mom. “No, she’s no longer taking two of them and the dose on the 3rd has been cut by 75%, only one Rx medication stayed the same” was the response to him. What can a doctor say when the medication he has prescribed caused more problems than it helped and Cannabis along with CBD oils have reversed those problems? In the photo below it’s easy to see the difference as this is what she looked like under his care without Cannabis:

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(Before Cannabis Oil Genevieve was hospitalized due to increased seizures caused by  and Rx Medication side effects and the fact they didn’t work either)

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Once Genevieve started getting oil not only was she ready for school, the OCD created wounds on her hands and forehead started to heal – read the follow up story here:  https://www.linkedin.com/pulse/genevieves-recovery-cannabis-compassion-continues-her/

When she started talking everyone was floored! At first it seemed as if she was just forming words by making sounds. I remember the excited text Anne Mari sent me right after she started using CBD and other oils, “She said ‘Momma’, I haven’t heard that in years.” The oils freed her from a world that seemed to be like a skipping record. Genevieve didn’t do much,  when she did she’d just repeat the action or behavior again.  She couldn’t walk too well as her gait was so poor.  She’d fall over trying to make it out of her room. All of that changed thanks to the Cannabis plant. Even the “Vaxxed” team that interviews parents of children like Genevieve who have Severe Autism occur until after multiple vaccinations noticed the difference in her. They’d seen her once before the photo below was taken. By far nobody had seen that type of freedom within Genevieve. Neither of us dwell on the vaccine issue as both my son Michael II and Genevieve had this type of reaction. We’re not into the huge controversy around it but do believe people should be aware of the dangers of multiple vaccinations in one day, and mostly – aware that kids and adults can find freedom in Cannabis! Why should we think of what’s been lost when the photo below so clearly shows the freedom that Genbug has gained!

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(Genevieve in her world of happiness)

As time progressed, all of us became closer and closer. As the world of compassion provision started closing quickly with new California laws,  the more time we spent together.  We had slowly became a family unit and it seemed as if the time was right – no more non stop traveling around on Amtrak and Greyhound (With epilepsy you can’t drive – even with Cannabis stopping the seizures) living out of a suitcase.  With how I felt inside about all 4 of the girls,  there was only one real answer to all of this – get married. It seemed as if I could hear the world applaud as Anne Mari and I got engaged! We haven’t shared our story on the network media, we both felt that we needed to keep an element of privacy but that didn’t happen as we shared quite a bit with millions across social media. Lately we both feel as if the world needs to know how well Cannabis works and how it can change and save lives – especially how it both saved and changed mine by giving me not just the gift of life but the gift of a very loving family.  Anne Mari, Fatima, Genevieve, and Sydney quickly became the 4 most important girls in my life.

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(Engaged! We’ll fill you in on the Wedding Date)

A year and a half later we enjoy life as a family. Together we visit with others that are intrigued by how much progress Genevieve has made. From school staff to the state program that runs her behavioral therapy – everyone is amazed. She walks around talking it up – from telling us of her colors to her continual request for ‘Daddy’ which really makes me smile! “It’s like I don’t exist anymore” Anne Mari will joke!  So many conversations occur because of the remarkable progress she’s made.It’s rubbed off on so many people it’s hard to count in person alone – as far as the world of social media I believe Genevieve has changed the lives of millions already. So many parents will send messages asking questions. These are people I’ve known for years to be extremely conservative.  Some that actually blocked me online for continually posting about Medicinal Cannabis undid that deed only so they could pick my brain about how they or their child could benefit from the amazing plant.

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Looking back at the beginning when she couldn’t walk through the house without seizing,  wasn’t talking,  and wasn’t even using her iPad? It’s just incredible to see the ongoing progress everyday. She loves the carousel so we used to go as often as possible.  It’s now closed down and the entire carousel has been dismantled and moved to a museum.  We don’t have the heart to bring her there and show her as she watches it on her iPad and in her own world.. that carousel still exists.  The nearest one is hours away and neither of us can drive. We’ll have to find something new for her although she’s been going there for over 5 years. At some point she’ll see it’s no longer there but for now we’ll try to replace it with something.  If you have any ideas please enquire as I’m very open to all suggestions. Someone suggested we get a horse but we’re not zoned for an animal like that and it would be a bit of work!

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(Pretending to feed the horses and talking about their eyes, ears, nose, hair, tails, feet, and people riding them had become Gens very favorite thing to do. Before Cannabis oil she would just sit on the horse)

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(This was our very last ride, I made a YouTube video so we could remember forever. If you have a carousel you’d like to donate – please contact me!)

Although I’m not a child, my own history with Cannabis is pretty intense as well,  In 1995 a career ending wreck on a pro tour caused severe bodily and head injuries and my life was changed forever on that date – Memorial day – the same day Christopher Reeve was paralyzed – so was I.

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For years, nearly a decade,  wheelchairs and canes were part of my life. Severe Refractory Epilepsy came along with all of that and was a serious hurdle as I traveled around the country representing kids in special education disputes (Due Process).  I started doing this back in 96 as my biological son is now 24 years old and is also severely autistic. He doesn’t have the ability to use Cannabis Oil and the difference is obvious between him and Genevieve. In September of 2013 I discovered myself CBD and the ingestion of Cannabis – seizures abruptly stopped.  Since that time Cancer has revisited twice and has been defeated by oil alone along with Lymes.

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If you think about it life with Chronic Lymes disease and an injury to the right eye from the wreck, that alone wasn’t fun but it’s over – Cannabis is the answer! I was legally blind in that eye until after using multiple types of oils over a several year period of time.  This plant can do incredible things for all of us. Most rely on doctors who don’t know the basics when it comes to Cannabis. I’ve even used oils to end an opiate addiction from pain meds given for cancer pain. If a doctor will not track Cannabis oils under the medication list I refuse to see them. For 4 years this has caused a successful medically documented case.  Cannabis kept me alive, and thankfully so, as now I watch and enjoy Genevieve’s awesome progress while sharing life with Anne Mari.  Little did I ever know that I’d be the one she calls Daddy… and not just here and there. It’s reported back from school that it’s her number one word! But she doesn’t always say it nicely.  Therapists, teachers, and especially mom laugh at how Gen and I will have our little debates. I like to keep behavior in check and she likes to push Daddy’s buttons sometimes to see how far she can go! It’s funny to listen and watch – not that different from any other Dad and 14 yr old!

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(Genevieve and I taking a walk near the pier. She’s such a happy young lady!)

Cannabis has done so much for me personally and it’s a never-ending story in regards to the number of people who benefit from the awesome plant and products people make with it. But I never thought that it would bring me love. I never in my wildest dreams imagined that Cannabis would make me a Daddy again. I’ve never had love like I do with Anne Mari.  We are a team working together to take care of Genbug the very best way we can. Of course Cannabis makes her life so much easier but she still faces an uphill climb to attempt to gain some of the abilities she lost over the years. Everything from manners to potty training has to occur. Potty training? At age 14 this is not something you expect to tackle with the severely autistic. Generally, at this age maladaptive behaviors are set in stone. Teaching new skills becomes way harder after the pubescent years. To have a child start talking when non verbal? Almost unheard of – which tells us just about anything is possible for her. How exciting! Bugbug as I call her had a plan from the beginning. She wanted daddy and when she found me I don’t think she had much of a plant to let go. From that moment I read that she was asking for me as Daddy my heart melted. I’m head over heels in love with Anne Mari so that worked out well!

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(Genevieve and Sydney coloring together – something that was never done in the past before Cannabis. Sydney is 7 but has taken on the ‘big sister’ role)

Even with Cannabis on board she’s a bundle of joy that does come with a huge obligation to care for her. We both handle that with a smile and laugh. Genevieve loves to laugh at the video’s she’ll watch.  Over and over she’ll laugh with me as I mock the Simpson’s convenience store owner episodes “Don’t you kids take anything! I’m watching you.. I’ve got eyes in the back of my head.” And, she’ll point to behind her ear saying ‘Eyyyyyyye”! The whole family enjoys Genbug like never before. She engages in play with her little sister who she once would ignore or avoid. Now its coloring together, watching TV and so much more. She loves to go for car rides. Whether it’s Nana coming over or her big sisters boyfriend she calls Buddy, she’ll do just about anything to sit passenger and laugh and smile as she looks out the window. Cannabis has truly renewed not only Genevieve’s life, but her whole family’s!

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(Older Sister Fatima, Anne Mari, Sydney, and myself)

We spend as much time as we can as a family.  Genevieve and her older sister have a very unique bond. Fatima recently gave us the news that she’s expecting a lil one of her own. Soon it will be Auntie Genevieve and Sydney, Gramma Anne Mari & Grampa Mike – we can’t wait!  Daily I have to thank Anne Mari for allowing me to be part of her awesome little family. It’s a blessing every single day. We both thank Cannabis, as without it this love story never would have happened. What’s even more intense is to think that a non verbal child that was seizing most of the day played the pivotal role in the creation of this family unit. She’s so full of love and life and spreads it to all of us, Genbug is our ‘reason’.

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(She loves her big Sissy Fatima so much)

Now we go to work. After reading this many think “What’s next”.  Well, quite a bit. Now that we’ve got the developmental delay moving into ‘developing’ instead – it’s time to get to work. Everyone from school staff to her home program has to step it up and work on her speech.  She loves her therapist at home. Due to privacy issues I can’t divulge name but can say they are the best of friends. I think that’s important.  As her therapist works on forming new positive behaviors along with new words as they emerge – it’s beautiful to see the bond they have grown.

Without a doubt my 14-year-old daughter has a future now,  thanks to Cannabis.  And a Daddy too!

It’s been a long journey since Anne Mari and I met, and we’ve learned so much and are thankful for all of it.  Together we work as a team, a family, to provide the very best for the girls. As far as the cannabis scene goes, the focus is on how the cannabinoids work, patient education, and to further the ability for patients like Genevieve to have doctors that are educated in how our bodies take in the plant or exogenous material in order for our Endocannabinoid System to work well and keep us healthy.

Now jump ahead 2 years and the family is still adjusting as Baby Leo, our grandson, was just born. I've moved out of my position at the American Academy of Cannabinoid Medicine and onward in life in both research of the plant, body's response, and more. 

It's always exciting times ahead!

Thank you for reading our story!

Mike Robinson,  Medicinal Cannabis Patient

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  • From Brianne Campbell

    Such an awesome story! Thank you for sharing Mike!

  • From 22

    Thank you Sharing!!

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Alex: CBD Is Attacking Behaviors – Autism & Epilepsy

Battling Autistic Behaviors With Cannabis In Control:

Alex, age 8, was diagnosed with autism just before he turned 2.  According to his mom Amber Luttrell,  “He had vaccines that caused injury”, and that’s how it all started. Like many kids with severe Autism that are non verbal, he’s much smarter than many would think. Just because he doesn’t talk definitely doesn’t mean he has nothing to say.  His mom reports that “he has lots of speech, ABA {behavioral}, Occupational  therapy,  and he goes to an AI school. He started getting aggressive I’m guessing out of frustration from not being able to communicate, he was banging his head and hitting others and even busted a class aide’s nose.” She went on to tell me “I refused to put him on pharmaceuticals. I decided it was time to try CBD oil.

“I had gotten some locally and tried it. Within 20 minutes Alex was calm so we continued using it. Aggression reduced,  he’s using an app on his iPad to communicate and is writing  things now. He’s more focused and relaxed,  Cannabis oil works amazing and has been a life saver for him.  Its been 2 months and I can not get over the change. I would definitely recommend parents try this before Rx Medications,  I have tried just a few kinds but have had success with them.”  She went on to tell me, “I’m trying out a newer oil that’s whole plant cannabis infused into MCT oil that I just made, so far it seems to be working very well. His behaviors are calmed”

“He hasn’t had a seizure in nearly 4 years” Amber told me of his Epilepsy diagnosis. CBD/Cannabis oil was sought out for him to help specifically with behavior. Like many parents that have discovered that cannabis works, she’s excited. When some parents find that nature works for their children like Amber has, they take action. She decided maybe she should get her hands a bit dirty and try to make something herself, “We have only tried 2 different oils so far but both worked, then I made my own.” And this is far from uncommon. There’s now various gadgets made to help people try to do it themselves coupled with the recipes and more shared online – without a doubt there’s a whole new movement of awakened people looking at nature for answers. No longer is the family doctor the one who we trust. Due to scares with medications, vaccinations, treatments, and so much more the average person is no longer trusting what the good ‘ol doc has to say.

Amber went on to tell me how she felt about making this bold move.  So many are quick to judge but nowadays Cannabis as medicine is by far mainstream. “It was the best decision I ever made. He has made so much progress and behavior issues have vanished by 75%.” She continued, “I urge all parents to try it before trying prescriptions, no side effects at all and totally safe.

It was a close call with the pharmaceuticals – Amber shared with me, “Alex’s aggression was getting bad and I needed to do something. The Doctor wanted to put him on Risperdal, I refused. I immediately tried the CBD oil, and within a half hour of the first dose he was calm. It was our miracle worker.” 

The story of Alex is still unfolding as his life changes due to Cannabis. Amber has shared with me that she’s going to try the full effect of cannabinoids as she can with Alex,  for now Cannabis has given him so much relief – and her as well.  All the activists out there please keep on talking it up! When asked where she learned of Cannabis oils and how they worked, Amber responded “I learned from friends online about its medicinal purposes for Autism.”

Mike Robinson,  Medicinal Cannabis Patient & Founder, Cannabinoid Institute/Research Center, Former Dir, American Academy of Cannabinoid Medicine 



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Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


CBD: What can't it do?

By: James Holley, Molecular Biologist/Research Officer at International Cannabinoid Cancer Research Institutes , with Mike Robinson, Co-Founder and Director


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Fig. 1. THC vs CBD. (1, clarified)

Introduction:

           CBD is the second molecule from Cannabis whose structure was identified by Dr. Raphael Mechoulam in 1963 by a careful NMR study. Originally, Cbd was thought not to be active at all (1), but it was since found that it has very low affinity for CB1 or 2, so low that at some concentrations it serves as an antagonist to the receptors (2,3) It may be more accurate to say that it is a negative allosteric modulator to them, which has been found for CB1: in other words, it causes cells to eat the receptors (4). This is a common thing for compounds with low affinity to trigger and perhaps why CBD is reported to be an antagonist without having the same side effects as rimonabant. It is also reported to have agonism at the 5ht1a serotonin receptor (5) which has anxiolytic and antidepressant effects in mice and rats.(6,7). 5Ht1a overall is a common target for anxiolytics such as buspirone that do not act as barbiturates (8). It also is an antagonist at both GPR18 and 55 which are thought to be kinds of secondary cannabinoid receptors (9) It is also known to act on TRPV1, the capsacin receptor, at the same affinity as capsacin but in a manner that desensitizes it instead of activating it. (10). It also inhibits the degradation of cannabinoids. (11) This is a very complex pharmacology for something that wasnt thought to be active. This was probably thought because CBD does not seem to distort the senses like THC does. However, being a 5ht1a mediated anxiolytic and cannabinoid receptor partial agonist/antagonist certainly qualifies it as psychoactive despite popular belief.

Use for Inflammation:

           One of the places CBD comes in handy is reducing inflammation in the gut. The first thing that should be pointed out is the involvement and desensitization of the capsacin receptor TRPV1 (10) which is responsible for triggering inflammation in the mucous membranes and the gut- a phenomenon known to anyone who consumes genuine salsa roja. The action at the serotonin receptor is also part of it . One study found 5ht1a in the gut paired with the mu-opioid (morphine) and dopamine-2 receptor. (12) If anything will slow down intestinal contractions, its morphine. Buspirone has been known to relax the intesines of guinea pigs. (13). The immune receptor PPAR-y is also affected by CBD, slowing down emission by intestinal glial cells of inflammatory cytokines and caspases. (14) Any increase in cannabinoid signaling by FAAH inhibition (11) is probably icing on the cake. I am certain that these pathways exist for other forms of pain and inflammation that people use CBD for.     

Alzheimer's disease:

           Did i mention glial cells got involved in that last section? Yes, that is correct, it can also affect the glial cells of the brain as well, and it turns out that activation of the PPAR-y receptor will put a stop to the production by neurons of the dreaded amyloid beta. (15) Glial cells, for some reason probably related to inflammation and injury, take amyloid beta and spin it into the tangled, fibrous form associated with Alzheimer's disease. (16) Cannabidiol puts a stop to their activation and generation of inflammatory cytokines. (17,18) It also stops their migration (19) and stops glioma (20) through a mechanism other than the classic cannabinoid receptors or TRPV. Considering the description by Massi et al. In (19) of earlier research indicating action at a receptor sensitive to abnormal cannabidiol, this means the primary action of regular CBD in this case is antagonism at the GPRs.

Anti psychotic:

           While we are at the brain, research is also in indicating the use of CBD as an anti psychotic as well as an anxiolytic. According to Lewke, Piomelli et al in (11), the inhibition of FAAH by CBD worked as well as amisulpride in treatment of psychosis, although previous studies showed no effect in 2 out of 3 treatment resistant cases studied (21). The main way in which CBD is thought to be acting as an anti psychotic is by attenuating effects at the CB1 receptor, and in this fashion is often desired as part of cannabis strains to attenuate the effects of THC (22). What makes it very strange as an anti psychotic is its apparent use to treat autism as well. In a very recent study by Dr Adi Aran, 61% of autistic patients improved after cannabidiol but in 10-15% had adverse effects including sleeplessness and irritability, possibly a better and safer shot at treating autism than any conventional medication or therapy has provided. (23) It is known now also that the cannabinoid system is linked to the oxytocin system, which is responsible for social interaction. (24)

Cancer:

           I believe i mentioned the cancer glioma in this discussion about the brain. The effect of CBD on glioma by blockade of the GPR55 receptor, among its other activities is to halt the MAPK pathway governing the cell cycle and halt the expression of enzymes on the cell surface that promote division and migration (25) This activity also extends to colon cancer cells as well (26), with PPAR-y, TRPV1, and even CB1 actvity also being necessary for anti-cancer activity in this case. (27) PPAR-y and COX2 activity were found to be involved in CBD destroying lung cancer cells, (28) while in breast cancer the cell cycle pathway was inhibited and an increase in reactive oxygen species and caspases was observed (29,30). CBD exhibits an extreme poly pharmacy in regards to cancer, inhibiting growth and proliferation through multiple routes.


So what cant it do?

           The question remains, where is this compound ineffective? I will return to the example of Aran's study where 10-14% of autism patients had adverse outcomes upon using CBD. There has been a case in Germany where a patient was using THC in the form of Sativex (a roughly 1:1 THC:CBD) to help his disorder. (31). If for some reason the GPR pathways have to be used over the CB1 and CB2 receptors, CBD will not only not work but will be harmful because it blocks GPR55. In a case of MBOAT7 mutation where the natural GPR55 ligand is not being produced, this would happen.(32) Also, cannabinoids do better when used concurrently. The effects of CBD on glioma were enhanced by addition of THC even under conditions of radiation therapy, the combination activating multiple pathways to apoptosis that were not present when either substance was used alone. (33,34).

Conclusion:

          Even though it cannot do everything by itself, CBD has an amazing poly pharmacy when it comes to some of the most difficult to treat and yet all too common conditions – cancer, Alzheimer's, autism, and IBS. It is also one of the safest drugs known to man, with far less side effects than any of the drugs its proposed to replace. Concerns have been raised about effects on the immune and reproductive system similar to concerns raised with other cannabinoids, but many of those occurred at ridiculously high doses in monkeys. (35) CBD is becoming popular because it has no effect on the senses like THC does yet relieves anxiety and pain. It may prevent cancer and dementia in a large section of the population if this trend continues.

References

1) R. Mechoulam and Y. Shvo. The structure of cannabidiol. Tetrahedron. 1963. Vol. 19. pp. 2073 to 2078.

2) RG Pertwee. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: D9 -tetrahydrocannabinol, cannabidiol and D9 -tetrahydrocannabivarin. British Journal of Pharmacology (2008) 153, 199–215

3) A Thomas, GL Baillie, AM Phillips, RK Razdan, RA Ross and RG Pertwee. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British Journal of Pharmacology (2007) 150, 613–623

4) R B Laprairie, A M Bagher, M E M Kelly, and E M Denovan-Wright. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. British Journal of Pharmacology (2015) 172 4790–4805

5) Ethan B. Russo, Andrea Burnett, Brian Hall, and Keith K. Parker. Agonistic Properties of Cannabidiol at 5-HT1a Receptors. Neurochemical Research, Vol. 30, No. 8, August 2005 ( 2005), pp. 1037–1043

6) TV Zanelati, C Biojone*, FA Moreira, FS Guimarães and SRL Joca. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. British Journal of Pharmacology (2010), 159, 122–128.

7) Leonardo B.M. Resstel, Rodrigo F. Tavares*, Sabrina F.S. Lisboa1*, Sâmia R.L. Joca, Fernando M.A. Corrêa and Francisco S. Guimarães 5-HT1A receptors are involved in thecannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. British Journal of Pharmacology (2009), 156, 181–188.

8)_Loane C, Politis M (2012). Buspirone: what is it all about?. Brain Research. 1461: 111–8.

9) Georgia Watt and Tim Karl. In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease. Frontiers in pharmacology. February 2017, Volume 8, Article 20.

10) Tiziana Bisogno, LumõÂr Hanus, Luciano De Petrocellis, Susanna Tchilibon, Datta E. Ponde, Ines Brandi, Aniello Schiano Moriello, John B. Davis, Raphael Mechoulam & Vincenzo Di Marzo. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. British Journal of Pharmacology (2001) 134, 845 ± 852

1) FM Leweke D Piomelli, F Pahlisch, D Muhl, CW Gerth, C Hoyer, J Klosterkotter, M Hellmich and D Koethe, Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry (2012) 2, e94.

12) Kentaro Kaneko, Masashi Iwasaki, Masaaki Yoshikawa, and Kousaku Ohinata. Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut 1-receptor coupled to 5-HT1A, D2, and GABA-B systems. Am J Physiol Gastrointest Liver Physiol 299: G799–G805, 2010.

13) Young Hoon Youn, Eun Ju Choi, Tadayuki Oshima, Hiroto Miwa, Hyojin Park. The Effect of 5-Hydroxytryptamine1a (5-HT1A) Receptor Agonist, Buspirone on Gastric Accommodation of Guinea Pig. AGA Abstracts, S-541, Su2047

14) Daniele De Filippis, Giuseppe Esposito, Carla Cirillo, Mariateresa Cipriano, Benedicte Y. DeWinter, Caterina Scuderi, Giovanni Sarnelli, Rosario Cuomo, Luca Steardo, Joris G. De Man, Teresa Iuvone. Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis. PLoS ONE 6(12): e28159, 2011

15) Caterina Scuderi,* Luca Steardo and Giuseppe Esposito*. Cannabidiol Promotes Amyloid Precursor ProteinUbiquitination and Reduction of Beta Amyloid

Expression in SHSY5YAPP+ Cells Through PPARγ Involvement. Phytother. Res. (2013)

16) Robert G. Nagele a,∗,1, Jerzy Wegiel b,1, Venkat Venkataraman c, Humi Imaki b, Kuo-Chiang Wang b, Jarek Wegie. Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease. Neurobiology of Aging 25 (2004) 663–674.

 17) Ana María Martín-Moreno*, David Reigada*, Belén.G.Ramírez, R. Mechoulam, Nadia Innamorato, Antonio Cuadrado and María L. de Ceballos. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease. Molecular Pharmacology June 2011, 79 (6) 964-973

18) G Esposito, C Scuderi, C Savani, L Steardo Jr, D De Filippis, P Cottone, T Iuvone,V Cuomo and L Steardo. Cannabidiol in vivo blunts b-amyloid induced neuroinflammation by suppressing IL-1b and iNOS expression.British Journal of Pharmacology (2007) 151, 1272–1279

19) Angelo Vaccani, Paola Massi, Arianna Colombo, Tiziana Rubino & Daniela Parolaro. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British Journal of Pharmacology (2005) 144, 1032–1036

20) Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P. Abbracchio, and Daniela Parolaro. Antitumor Effects of Cannabidiol, a Nonpsychoactive

Cannabinoid, on Human Glioma Cell Lines. JPET 308:838–845, 2004

21) José Alexandre S. Crippa et al. Cannabidiol monotherapy for treatment-resistant schizophrenia. Journal of Psychopharmacology 20(5) (2006) 683–686.

22) Amir Englund, Paul D Morrison, Judith Nottage, Dominic Hague,

Fergus Kane, Stefania Bonaccorso, James M Stone, Avi Reichenberg,

Rudolf Brenneisen, David Holt, Amanda Feilding, Lucy Walker,

Robin M Murray and Shitij Kapur. Cannabidiol inhibits THC-elicited paranoid

symptoms and hippocampal-dependent memory impairment. Journal of Psychopharmacology 0(0) 1–9, 2012

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Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Research Shows Major Flaws In Epidiolex Pharmaceutical CBD

Key pharmacological differences between side effects of refined, pharmaceutical CBD formulations and whole plant extracts:

By: James Holley, Molecular Biologist, Scientific Officer, Mike Robinson, Co-founder, Research Institute, and Dr. David Ostrow, M.D., Research Director

International Cannabinoid Cancer Research Institute (Draft 5)

With review by:  (Pending) (This is not the Final Draft)

Abstract:  (This is not the final draft, the final is being submitted for Journal Publications)

Recent studies on the effectiveness of cannabidiol in the rare seizure disorders Dravet Syndrome and Lennox-Gastaut syndrome have prompted a biopharmaceutical company to perform clinical trials of its own to bring a cannabidiol based drug to the American market through the process of FDA approval. Side effects were very prevalent in 79% of all patients taking a refined CBD product, some of which were severe like thrombocytopenia and transaminase elevations in the liver. However, there are indications from studies done with cannabidiol-rich cannabis extracts in Israel that indicate that less side effects (46%) are achieved with a natural cannabis plant extract containing a 20:1 ratio of CBD to THC. This paper seeks to answer why refined cannabinoids have more side effects than the natural cannabis product, as well as the possible etiology of said adverse reactions. Also discussed are other attempts at affecting the cannabinoid system from a singular standpoint. Ultimately, the cannabinoid system works by way of multiple molecules affecting multiple receptors at once – the entourage effect, and thus such singular approaches to treatment by way of the cannabinoid system are not effective. Traditional plant extracts contain many compounds in addition to THC and CBD that contribute to the medical benefits of cannabis.

Introduction:

Recently, a formulation of cannabidiol was approved by the United States FDA. It is extracted from hemp grown using conventional agricultural methods like pesticides and fertilizers and extracted using supercritical carbon dioxide, crystallized, and put into a formulation with sesame oil, strawberry flavoring, alcohol, and sucralose, to be used alongside existing anti-seizure medications like clobazam. This differs sharply from the conventional course of cannabis medicine, which is to use whole, clean plant extracts to treat epilepsy and to gradually discontinue use of conventional pharmaceuticals. The question is, is there truly a difference? It might be argued by some that a compound is a compound, carbon for carbon, and thus it would have the same effects. However, it is sometimes the case that the pill binder or other carrier causes a medication issue. A review of the research must be done to find if natural plant extracts have an advantage over synthetic delivery systems.

Review:

During an open-label trial of pure CBD with Lennox-Gastaut and Dravet patients, 79% of all patients reported side effects. The most common side effects reported were somnolence (25%), decreased appetite (19%) diarrhea, (19%) Fatigue, (13%) Elevated liver enzymes, (7%) Convulsion, (11%) Increased appetite, (9%) Status epilepticus, (8%) Lethargy, (7%) Weight increased, (7%) Weight decreased, (6%) Drug concentration increased, (6%). Serious side effects in 30% of patients included status epilepticus in 6%, severe hepatotoxicity in 1 patient, and hyperammonemia in another. One patient died but it was ruled to be part of the course of their disorder and not a drug effect. The liver and urea cycle side effects were related to co-intake of valproate, the pre-existing medication. (1) The official FDA side effects include insomnia (11%) irritability (9%), a chance of suicidal ideation “common to anticonvulsants” and a 33% higher chance of infection. It makes no mention of any interaction with valproate (2) CBD was also found to increase the active metabolite of clobazam, a common medication for refractory epilepsy, by blocking cytochrome p450 enzymes CYP2c19 and 3A4. (3) All side effects were for a 70% overall seizure reduction and 52% reporting a decrease of 50% or more.

An Israeli study of cannabis versus epilepsy, however, used natural extracts with a ratio of 20:1 CBD:THC. When administered to children with epilepsy, seizure reduction occurred in 89% of patients and 54% achieved over 50% reduction. Only 7% had an increase in seizures, and only 7% had restlessness and irritability. 34/74 patients in all had side effects, or 46%. (4) Interestingly enough, Aran noted a similar prevalence of irritability and restlessness in the Israeli CBD trial for autism, further underlining the connections between autism and seizures. (5). In all of these trials, none of the patients were on other medications concurrently – it is common practice in cannabis medicine in both California and Israel to withdraw from other medication. No hepatic side effects were noted.

These two studies are not alone in their findings. A recent meta-analysis of CBD studies on Dravet, Lennox-Gastaut, and CDKL5, 5 of them using purified CBD and 6 of them using a CBD-rich extract, found more improvement in general with CBD-rich extracts. However, the number of patients experiencing a reduction of 50% or more held steady between the two groups at 39-42%. The CBD-rich extract group had a lower effective dose on average, 6.1 mg/kg while purified CBD required 27.1 mg/kg. Purified CBD also tripled the rate of both mild side effects such as appetite alteration, sleepiness, gastrointestinal disturbances/diarrhea, weight changes, fatigue, nausea, and severe side effects such as thrombocytopenia, respiratory infections, and alteration of liver enzymes. (6)

Discussion:

There are two possible explanations for the reduced side effect profile and increased efficacy of the whole plant extracts versus the refined CBD product now on the market. One of the main things that stands out is that in America, CBD was investigated as an adjunct to existing AEDs while in established cannabinoid medicine, patients are gradually withdrawn from existing drugs to use CBD. Drug interactions involving the liver are more common with multiple medications, and this is what was shown in the Lancet study. (1) Another is that the Israelis and others used whole plant extract with a small amount of THC in a 20:1 ratio. There is a phenomenon known as the “entourage effect” where the action of multiple cannabinoids and other plant compounds known as terpenes exhibit effects at a variety of receptors. This mimics what the endogenous cannabinoids do: they are synthesized at the same time in precise ratios, on demand, to exert precise effects on receptors. A neutral carrier made of sesame oil, strawberry flavoring, and sucralose has no synergy with CBD whatsoever. (7,8) Meanwhile, the terpene linalool has been shown to decrease glutamate binding and limonene and caryophyllene together have been shown to limit hippocampal excitability. (9,10)

Fig 1: Sucralose (In Study)

Fig 2: Ethyl Methylphenylglycidate (In Study)

Sucralose is common to use in a pediatric formulation. Although regarded as safe by the FDA, sucralose has since been find to alter glucose uptake and hormonal response to glucose, including of course insulin, and cause obesity in rats. (11) This effect is controversial in humans: some studies have shown no effect on glucose absorption in acute administration of sucralose in humans. (12) However, increased absorption of glucose was found, with corresponding increased insulin levels and decreased insulin sensitivity. (13) The strawberry flavoring ethyl methylphenylglycidate is another component with more questions than answers. It is registered as a pesticide ingredient with the EPA, and in the filing, LD50 numbers in rodents are noted and teratogenicity was noted in chickens. (14) NIH Toxnet cites studies that say that at 10000 ppm in rat feed caused growth retardation and testicular atrophy, while at 5000 ppm caused the demyelination of the sciatic nerve and can provoke hypersensitivity reactions with chronic exposure. (15) But more directly, there were two cases noted where strawberry flavoring caused reflex seizures with initial gamma band activity in the anterior inferior insula, with decreased activity in the hippocampus. (16) This is of interest because CB1 receptors are connected to gamma band activity and are most active in the hippocampus. (17,18) Meanwhile natural cannabinoids and terpenes are metabolized normally, with possible positive effects on blood sugar and metabolism and no added risk of seizures. (19)

Fig. 3. Synthesis of the synthetic cannabinoid JWH-018. (within study)

There have been other attempts to use a singular compound to affect the endocannabinoid system. For several years Dr. Piomelli at UC Irvine and his lab were involved in the development of FAAH inhibitors – substances that inhibited the breakdown of endocannabinoids. (20) The aim was to increase the level of 2-AG and anandamide in general so as to produce effective relief for a cannabinoid deficiency without any psychoactive side effects. Things seemed to go well in animal trials using URB597. (21) However, human trials of a similar compound BIA-10-2474 in France ended in disaster causing brain damage. (22) The problem in this case may have been off target inhibition of lipid metabolism in the brain, causing something similar to Tay-Sachs disease. (23) Piomelli predicted this might happen and he and other scientists disagree with how the French company went ahead with human trials. (24) Another famous attempt is the CB1 antagonist rimonabant – it was briefly tried as an appetite suppressant before it was found to cause anxiety, depression, and suicidal thoughts, causing Europe to ban the drug and major drug companies to stop researching the whole class of drug for human use. (25) Synthetic CB agonists, created to study the cannabinoid system, escaped the lab and became a whole new drug problem in the form of “Spice”. These chemicals have caused deaths and overdoses nationwide, causing New York to ban them on September 13, 2012 and the USA to follow suit, though new compounds are made every day. (26)

Fig. 4. THC

Another example of cannabinoid mono therapy is the THC pharmaceutical Marinol. After Professor Raphael Mechoulams discovery of THC as the main active principle in 1964, it took 22 more years for the FDA to approve its use as an appetite stimulant for AIDS and cancer patients, and only when all else had failed. (27) A 1998 study found a low potential for abuse and no indication of patients chasing the drug. (28) Side effects noted included strangely enough, vomiting and abdominal pain, psychiatric side effects including depression and paranoia, and low blood pressure. It has the same onset time of 60-90 min as cannabis edibles but only lasts 2-4 hours: many patients report edible cannabis made using the whole plant lasting 6-8 hours or more and find Marinol to be an inferior product (29,30). Concerns about mental and developmental health have been raised over THC and high THC cannabis concentrates, however CBD has been shown to moderate or even cancel out the effects of THC. (7). Hemp extracts are known to contain a small amount of THC even when derived from a CBD-rich cannabis cultivar and are known to produce positive test results for THC even in users of CBD hemp products. (31) The United States DEA has stated that small amounts of other cannabinoids will also occur in all cannabis extracts, even those that purport to be CBD only – unless synthesized de novo, CBD isolate will always contain small amounts of THC when extracted from a plant. Even chromatography is not perfect. If so, CBD medicines should warn of this at least for the purposes of drug testing. (32)

Fig. 5. CBD

But how exactly does CBD by itself produce adverse effects in a small percentage of seizure and autism patients when it is well tolerated by 90% of the patient population? Even whole plant extracts are not tolerated by this group. This is where emerging science may provide an answer. CBD is mostly antagonistic towards the CB1 and CB2 receptors, with a Ki of 3500-4000 nanomolar. (33) It has been found to be a negative allosteric modulator of both of them. (34, 35) It is also an antagonist at GPR55 and 18 which have been shown to be secondary cannabinoid receptors (36,37). THC, for example, is a full agonist at GPR18. (38). Mutations in MBOAT7, which produces the natural ligand lycophosphatidylinositol for GPR55, are linked to autism. (39) A duplication of the region containing GPR18 was linked to another case. (40) It is thus possible that autism and seizure cases exist where the proper rescue pathway is through stimulation of the GPR receptors and not via the multiple, mostly antagonistic actions that CBD is known for. CBD and other cannabinoids are also known for having a bell-shaped dose-response curve. In an experiment with mice using CBD-rich extract, the anti-inflammatory and pain relief effects peaked at only 5 mg/kg, which is close to the average dose found in CBD-rich extract studies. However, use of whole plant extract was able to overcome this and make the relationship correlative. It is possible that the dose used in studies using isolated CBD is too high in general and given the prospective study design in those studies versus the retrospective design used in the extract studies this remains a possibility. (41,6)

Conclusion:

Ultimately cannabinoid medicine must be based on a sound understanding of the underlying biological systems involved, as well as the unique human physiological response to inert synthetic ingredients that are proven herein to be the causation of most, if not all the side effects listed by the F.D.A. on the new pharmaceutical, and that the vast majority of these side effects are not from any extract of Cannabis, including CBD. As well, the conventional approach of isolating a single active principle and using it when prior study does not support such applications within the Endocannabinoid System, where multiple components are manufactured by the same enzymes in ratios to exert an effect in concert on the system in whole. More research is needed to determine proper ratios for specific conditions, as well as genetic testing developed to determine appropriate course of treatment. In all, neither CBD or THC alone are as opportune as a mono therapy without other accompanying elements of the plant including phytocannabinoids and terpenes. Efficacy in study is reduced when one cannabinoid is isolated away from the balance of the cannabis plant. The side effects stemming from the addition of synthetic inert ingredient to sweeten and flavor are found to be a risk of consideration for further study. When combined with other pharmaceutical medications, specifically seizure medications, the side effects are unnecessary and again, in a large part a cause of inert ingredients. In conclusion, the removal of Cannabidiol from its accompanying plant terpenes and other cannabinoids and it’s placement into a carrier consisting of sucralose, a synthetic strawberry flavoring, and sesame oil also reduces the effectiveness and heavily contributes to the F.D.A. listed common and severe side effects. There is no way to conclude that the new pharmaceutical compares to whole plant extract in any scientific way other than containing an isolated cannabinoid. Regarding the warning for specific populations that based on animal data the pharmaceutical may cause fetal harm. There is sufficient data, as indicated in discussion, that inert ingredients within this newly approved CBD pharmaceutical for the US Market have already been proven to cause harm in the unborn fetus, and not the cannabinoid. This would explain the special warning upon the current FDA approved drug. Moreover, since CBD can never be fully isolated, the packaging of CBD medicines should warn about the presence of THC.

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A Note from Mike: As a patient with severe epilepsy and a father of not one but two children with it? I will let the research and study we have done speak for itself for the most part, but I’ll be backing it with public appearances and interviews to head off the ‘side effect’ warnings that we WILL SEE on TV and hear on the radio. This is serious – CBD is under attack and by the use of a very disturbing way of creating a product for children. The topic of inert ingredients in CBD products has been ongoing since inception of the many different types of oils we see on the market. Never have I personally witnessed anything quite like this. My opinion on this all will come in a future blog, at this time we’re doing initial publishing as there are multiple entities, mostly Epilepsy Societies and Foundations, that are awaiting this document for analysis and publication.

A good full extract CBD oil, which works well for many but not all, you will not find this on a pharmaceutical store shelf nor will you find via a prescription by your doctor who likely knows very little, if anything, about Cannabis or how to prescribe the new drug. Many are learning which is a great thing!

Full Spectrum CBD products of the best type, many times will come from the same type of Cannabis flower or bud that the THC crowd loves. Genetics have allowed Cannabis to advance quickly.

There’s simply no excuse for bastardizing the plant in a manner we see here in the extremely factual and well planned research study above. Over 50 well known researchers globally weighed in, and many with varying opinions. But the facts that James and I initiated seemed to be the ones that most are paying attention to. Inert ingredients coupled with a single cannabinoid delivery created through an odd lab process create a product that fails to meet efficacy standards and meets all non standards of causing side effects that include increased seizures. This makes no sense unless the plot in releasing this drug that will only serve 1/2 of 1% of the world of Epilepsy was to once again marginalize cannabis by using already marginalized people like myself – those with Epilepsy. Those the world writes off for the most part anyway.

The inert ingredients within the newly approved Pharmaceutical CBD are not only in a large way responsible for key very concerning side effects within it, but are known to promote seizures in a big way – proven with studies on the exact same flavoring. Why would a pharmaceutical company do this? But it gets worse, these are carcinogens, and are blatantly unsafe in my strong professional opinion.

The fact that this ‘CBD only’ pharmaceutical can cause a positive THC test per the DEA rule 7350 yet has NO WARNING? Now that seems beyond dangerous to consumers – it’s downright irresponsible on both the pharmaceutical companies behalf and the FDA/DEA combo who seem to not read each others inter office memos.

Thank you,

Mike Robinson, Medicinal Cannabis Patient and Founder, The Institute/Research Center

Related comments

  • From JADEO

    10% side-effects. That is a crazy high number. The larger concern, the public will not understand this product is not 'true plant-based' CBD and as a result lump the negative side-effects to the plant-based product. #Education

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