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From acne to anti-aging, this special interest group is for those that are interested in skin, hair, nail care and more! Join this group to read, learn, share and discuss more on these topics. Your safety is important to us. Always seek medical advice from your own doctor before starting any wellness treatment and report any violations of our posting standards. Stay Informed. Stay Healthy.

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Kimr Cannabis, Hemp and Beauty 5 days ago / Hamilton, Ontario

Hey everyone, I’m in my 50s and still struggling with acne. Does anyone have any suggestions? I’ve heard CBD is magic.

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  • From Janelle Simone

    Hey Kim, great question. I haven't used cannabis related products for acne, however, I do know a few people who have and they have seen great results using CBD.

  • From Kimr

    Hi Janelle, good to hear people are having success clearing up their acne using CBD. I hope to find out what they are using (CBD Oil, CBD pills or creams) to clear up their acne. I would appreciate any information, thanks

    • From Connor Christine

      Hey Kim, I've really been struggling with cystic acne over the last 2 years. I'm currently looking into topical creams and oils because I've heard that it helps. I'll connect with you on here, and let you know if I have any success. I'm just really trying to do a lot of research before I make my first purchase because as you probably know if you've been researching like me, is that these products are rather expensive. Hopefully we'll talk soon Kim!

Connor Christine Cannabis, Hemp and Beauty 2 weeks ago / Hamilton, Ontario

I have always struggled with my skin, in the winter it’s super dry.. in the summer it’s super oily and to top it all off my acne gets pretty bad. I’ve been interested in buying a CBD serum for a while now, has anyone tried something like this?

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  • From Connor Christine

    Picture from @horaskincare on Instagram!

  • From Janelle Simone

    I have my own bag of skin issues too, and have heard people mention products like these as solutions. I'm definitely going to be looking into it as a potential solution

  • From Tara Martin

    Any idea on price point? I’m working on an article, with lovely images, of my battle against cystic acne with CBD. Stan tuned!

Lindsay Le Blanc Cannabis, Hemp and Beauty 2 weeks ago / Toronto, Ontario

I had to do a double take! I thought I was seeing the first big brand to bring a cannabis cream to market.... but they are using the words "cannabis seed" on a hemp skin care product. This could be confusing to consumers! Has anyone tried it?

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  • From Janelle Simone

    Never tried it, but have noticed a number of beauty brands taking liberty with the term "cannabis" as an ingredient but when you actually read it has 0 cannabis or its derivative of cannabis. Interesting to see how this will eventually be regulated.

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22 1 month ago / Caledon, Ontario

https://www.forbes.com/sites/janetwburns/2018/09/30/we-should-be-pouring-time-and-money-into-hemp-period/ HEMP most people had no idea what it was a mere 3 years ago. NOW almost everyone has heard of it. POWER of a movement

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Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Fighting Epilepsy and Cancer with Cannabis

The Fight Against Seizure Triggers Persists. Controlling Them With Cancer Is A Unique Battle:

One of the biggest questions I get asked after five years of using Cannabis to stop the seizures and so much more is “Mike, how do you do it and what do you use?” That’s a very tricky question to answer for two reasons. There’s multiple types of Epilepsy and Cancers as well, so I wouldn’t want to infer that whatever I’ve done would work for another as there’s billions of human beings on this planet with individual metabolisms and physiology so everything works differently on everybody. That’s the basic philosophy used. I also use so many different delivery methods especially for Epilepsy – but that statement gains more attention and will immediately bring up another question “What is a delivery method”. Let’s go through some of the common questions that are asked and I’ll give you my version of the answer.  By far this is not limited to Epilepsy as treating multiple health problems successfully with Cannabis is how I stay alive.  My hopes are that someday everyone has access to the plant and it’s incredible healing powers – until then let’s learn together!

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I am no ordained ‘expert’ in my opinion – I’m just a patient like you that’s gained a different type of perspective by having involvement in the past with large compassion programs and over the past year as the Director of Communications and more for the American Academy of Cannabinoid Medicine. I work around "experts" and with them, but we don’t see eye to eye on everything as I believe patients have outgrown doctors in knowledge on how to dose and use cannabis. Nowadays the experts generally DO NOT have M.D. behind their name. My own exposure to the 'experts' in Cannabis so far has been a massive let down, But, doctors have started to learn more and there are a few experts that know so much about the body and the Endocannabinoid system but seem to not understand many of us that have theories regarding the difference in human physiology – the fact that we’re not universal creatures. This, I believe, is why Rx medications have failed in an ugly way for the most part. Now don’t get me wrong, many people also stay alive due to the modern treatments or pharmaceuticals.  Others, however, will perish to overdose, serious side effects, with cancer the known possibility of death due to the type of ‘modern treatment’ – or like I was and am – ill due to the simple lack of plant medicine properly delivered to my body over a period of time. I’ve used cannabis for decades but I’ve only used it right, as an effective treatment,  for 5 years. And that meant ingestion of the plant in one way or another.

Now I've stated the Global Cannabinoid Research Center, an educational entity just created to provide whats needed for Collegiate Academics. Of course this is also what's needed by the Clinicians and 'Specialists' of the world that are not too involved in Cannabis and need continued medical education. Recently, I presented on CBN and the 4th World Congress on Cancer Medicine in Moscow, Russia.  Next year I'll be doing a workshop on Cannabinoid Medicine in Tokyo, Japan at the 6th World Congress on Cancer Medicine and Survivorship and holding a 3 hour educational seminar for the thousands of doctors and scientists that attend. As well they've passed on the honor of being an Organization Chair Person, or in other words the small group that oversees the entire event as specialists in our field. 

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While fighting my own battles and assisting others, it’s always been inspiring to watch the kids that fight so hard. Whenever times got rough and alone I’d be picking myself up off the floor or lying in a hospital bed after the fact, whether in ER or already admitted, thinking of the kids that didn’t know what was happening to them always made me toughen up.  Now I have Genevieve with me daily as a hero that fights seizures – and with the plant as her armor. If she can do it,  so can I and we both rely on the same thing – the Cannabis plant and our loving family. As we both are fighting the same thing in essence,  Severe Refractory or Intractable Epilepsy, the type of protocol is somewhat the same. Minus inhalation for her of course. I’ve found that I’m not alone – other adults that are doing well with various types of Epilepsy are using both ingestion and inhalation as well. I’ll go deeper into that as it seems to be a very intense subject that many ask about quite often.  With kids we keep it to ingestion as long as possible and try the most subtle approaches unless otherwise is indicated, such as with our Genbug

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Q. What is a Delivery Method? 

It’s how you use Cannabis. Some will smoke or vaporize the actual flower from the plant, and others will vaporize (using vape pens often with replaceable/refillable cartridges). Some vaporize by ‘dabbing’ of concentrates of THC, CBD, or even both as I do. The most medicinal way in my opinion is through digestion of oils that have concentrated amounts of Cannabinoids. THCA, THC, CBD, CBN, CBC, CBG – so many different cannabinoids we know of and many others we don’t – all in this amazing plant that we can literally eat raw or take in oils and more. There’s also salves and other products for the skin including anti aging that I’m not including in the ‘inhale/ingest’ discussion. Through the years there was even a Tea created and the name coined after my love of purple! There’s suppositories,  trans-dermal patches, chewing gum, edibles of all types – the list goes on and on. But, if you stop and think about it much of this can be divided into two types of delivery.  Internal via digestion or by Inhalation. All deliveries have a different effect. The biggest being that inhaling higher THC cannabis either by smoke, extracted oil vapor, or concentrated dab vapor – the same thing happens. Signaling occurs in the brain with a bit hitting the body.

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Q: What’s the difference between smoking or vaping and ingestion?

Quite simply the inhalation method tends to gain the attention of Cannabinoid Receptors located in the brain which is why the user gets a fast ‘head rush’ from THC and other activated cannabinoids that cause this as discussed. The length of time the person is ‘medicated’ is much shorter with inhaling than via digestion.  I use inhalation to give me immediate relief from anxiety and other symptoms (aura types) that are associated with the triggers of Epilepsy. By inhaling a strong THC concentrate I find that I am immediately medicated much more than any Rx rescue medicine, but others prefer a different delivery for the exact same feeling of relief whether from anxiety, pain, or other health issues. So many in our society have slowly changed their position about people that smoke ‘weed’ ‘pot’ ‘marijuana’ – there’s so many names for Cannabis it’s incredible. Ingestion on the other hand tends to activate the entire body’s receptors creating a much more intense medicine. Instead of hitting only half of the receptors of the Endocannabinoid System ingestion of a full spectrum THC plus other cannabinoid infusion will hit all of the receptors.  I may not be seizing radically by the day, but certainly feel like I might at times. Now some have reported the Cannabis CBD or that which comes from buds to be working extremely well – I’m one of them as I use it for all of us in the family. I don’t have quite the same luck with isolated CBD, but others report that it helps them. I’m looking for control of a radical type of Epilepsy and Cancer as well. We treat multiple ailments from Autism, Anxiety, and Arthritis in the A column alone, one plant to replace multiple medicines.

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Some  professionals in the industry prefer Cannabis and Hemp be the terms used. Most dislike the word Marijuana but others simply don’t care. I know multiple older cannabis experts that still call it dope! The decades of terminology that seems to stay put with those that have been using it far longer than those that have been looking to profit from it I believe are here to stay despite the desires of many. But lets get onto healing with the plant, that’s what truly matters! Inhaled Cannabis is the term I’ll use as I don’t care about the politics of the words, I care about people learning how to stop seizing and feeling better from whatever the health issue is. The world doesn’t realize what we go through.  The amount of anxiety, loneliness, and depression people with Epilepsy and other illnesses have is internalized and bears an incredible weight upon the person. With Epilepsy – over 50,000 people perish annually, often in their sleep. Some of my online friends will check in with a simple message “I made it” in regards to living through the night. Many can’t imagine that fear as they do not live with a label known to take lives with zero notice.  In our world we’re very aware that one of the top neurological disorders in America is at the bottom of the list for funding of research. Now let’s talk about ingestion of cannabis to rid us of these problems!

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Q: Mike, why do you like ingestion and inhalation both? 

Wow, that’s got to be one of the top questions I’m asked as well. When you ingest cannabis in it’s various forms it does much more than hit your brain’s main endocannabinoid system and the receptors within the cerebral cortex, instead you’re looking at exciting or activating ones that are located throughout the body and concentrated in the CNS and immune system – literally hitting all of it’s receptors vs half of them.  So when I ingest oils they move throughout my internal organs and treat me from the inside out. Since I’m also fighting Cancer, this is imperative. I also use topicals at times, cannabis infused in oils put directly on the skin which I don’t include in the inhalation/ingestion topic.  Even if I wasn’t in a cancer recurrence I’d still be using some infused oils daily as the combo of both inhalation (for me I like vaporization but also smoke) and ingestion is the key for both myself and Genevieve. Without ingestion of oils I know neither of us would be doing this well. I know it keeps me alive. As an adult inhaling it, I believe in my own theory, it activates the entire system by making what we’ve ingested come to life in a whole different way – much more medicinal and much more value by combining these intake methods.

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It also takes the people that surround you to be aware of what you need and to be responsive for you. Without the team we have here it would have been beyond difficult to battle the problems that still face both of us. Both Gen and I still have Epilepsy regardless of seizure control. We both ingest quite a bit of infused MCT to gain the cannabinoids we need along with the ketogenic ability of the base oil itself.  So whatever you are using make sure you’re eating some of it or ingesting – it’s a must. Also make sure your ‘team’ is aware of what you use and whatever Rx medication you still take. Without a quick response from Mom both of us would be subject to what a trigger can do. I like the fact that infused MCT can easily be used as a rescue – it takes 4-5 ml but that’s not much and it’s great for the health. One thing we always aim to do is rescue before a problem occurs, and it works.  With a ton of autoimmune difficulties some medications have caused side effects that trigger a neuro response. Thankfully Genevieve and I have a team from the youngest to oldest in the family that are all knowledgeable on our specific needs.

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Back to digestion and inhalation – I need both to do the job. I’ve found many times that both used simultaneously, literally eat some infused MCT or Olive Oil, and then dab or smoke as it’s melting in my mouth. seriously does the trick and can last for many hours. I call it the double whammy and it stops any feeling that is associated with Epilepsy, Anxiety, PTSD – even depression and symptoms of these neuropsych often situational multi diagnostics are within just about every illness imaginable. Sometimes I’ll use a stronger Super critical CO2 extraction that’s been turned to ‘THC Distillate’  if its needed. I continue to use various products as I’ve found there’s few others I can talk to (sometimes nobody else) that’s recovered from the same diagnosis – Severe Refractory Generalized Epilepsy and has found a way to manage it with Cannabinoids. Finding others that have it documented in medical records is even harder. One thing I do see too often nowadays are claims by people that are ‘seizure free’ – we don’t know if that’s the case if an EEG isn’t connected to us. Sometimes I see it along with an ad for a product – nowadays I’m very leery of this.  I try not to associate myself with products at this time as I’m not a walking ad for anything but the plant. Maybe that will change, for now – I’ll stay a patient. After all, there is a huge industry out there and people will do quite a bit to sell products, although I find that this is limited and most have good intentions. Let’s get back to nature and I’ll try not to get off track!

Back to the battle for independence and wellness. For me,  it takes changing the strains and how I intake it.  Many get hung up on what strain and ratio to use. I literally don’t care as long as it’s clean cannabis and it’s got the terpenes and more intact as well as fitting the purpose. For example I’m not looking for a straight sativa or dominant hybrid alone but will mix it with Indica to make a nice mix. I don’t go off of ‘keep it the same’ – I go off of ‘change it up’. Why? Because keeping it the same has proven to not work unless the same is of a quality I don’t see on the market but would love to see created and available for everyone – that would take a change in federal law.  Anyway, after awhile it’s became intuition in deciding what to use or even make – I literally know my body and what/when it needs. My EEG may be clear but I still have problems at times. When I ingest infused oils they are lower in THC and are subtle, if it is a full extract thick black oil for example it’s much more intense and high in THC – definitely can cause a bit of a medicated feeling like inhalation does. I prefer to infuse MCT coconut, olive, and other oils infused with cannabis vs. using the strong RSO types as there’s multiple issues with both the long term use of oils prepared with solvents and whether or not the oil is clean.

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Dr. Alan Schreiber is a farmer and researcher in Eastern Washington where he grows a variety of crops including marijuana. (Photo by Rajah Bose) He’s also known for having expert extraction on site with the cleanest of oils.

Stopping severe refractory seizures that can and do kill means sometimes you may have a partial onset – or the start of one. This comes with panic and so much more – those of you with Epilepsy or any health issue associated with panic know exactly what I’m speaking of. Sure, the neurologists can’t find a trace of it in the short EEG tests they do on me –  there’s enough cannabinoids in me to literally beat it. “Great job” I might tell myself, but still  Epilepsy will forever be part of life and the “Purple Family” of Epilepsy Warriors and parents I adore come with that – must say I don’t mind that part at all!   Regardless of our diagnosis, illness, or struggle  – we’re all in this whole Cannabis fight together. But more importantly we’re all on this earth together to help each other.  We do this by gaining knowledge of people’s specific needs and carrying out acts of courage nowadays that I call kindness. We live in a brutal world, that can’t stop any of us from spreading the word of how we treat our problems with Cannabis or how we should be loving each other.

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Does Cannabis stop the seizures for me? YES.  How? By interrupting the interrupted signals in my brain and redirecting them to where they should be going. That’s the simple way to explain what I’ve learned via treating myself, others, and extensive research. Sure I could quote studies and so much more, but I’ve found many of them to be highly objectionable. How could the application of cannabinoids or cannabis on me be compared to a rat, mouse, kangaroo, or even a small group of other people? We’re all unique. Some people respond really well to CBD. I did at first with vape pens and ingestion of it coupled with ingestion of raw cannabis. That’s literally how I stopped seizing why I look at both of the basic delivery methods as the way to go. At first CBD alone and ingestion of raw Cannabis was the trick to gain full control but I found that changing what you use or your ‘protocol’ is imperative at times.

A good friend with Epilepsy came and saw me and we discussed this. A person that never inhaled before started doing so with very small amounts along with a THC/CBD combo infusion of oils. Guess what? It also worked for her – another adult with Epilepsy that had serious seizures interrupting life is now experiencing the ‘Awakening’ as I call it. It’s when a person stops seizing and starts remembering life and past events.  Medicated on Cannabis is how I remembered all of the past that I had forgotten due to a 1995 high speed auto racing wreck.  For others the exact same thing happens, if indeed, they stop a severe seizure pattern. It’s an incredible feeling. Much like going into remission using cannabis – and I’m not talking cancer. It could be addiction, alcoholism, Lupus, Lyme’s, Pain Management or literally any health issue that’s overcame and causes a person to have a renewed life based on the use of Cannabis.

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When I first gained control over severe back-to-back grand mal seizures in 2013 the awakening was incredible. It almost scared me and still does some days. Having a life again means that people are no longer going to be watching over you as they did when you had Epilepsy that was very active. With any health issue that has others on edge one gets in a pattern, and that pattern is indicative of reliance on others vs. yourself. Suddenly the reliance on others ends because no longer are you ill. Boo-hoo so one would say – You’re free! But, that’s why I wanted to write this blog! Even today as I use multiple strains and multiple products I still have this edge to me at times, I do right now as I’m typing. On edge, hard to explain but easy with others that have Epilepsy for some reason as most know exactly what I’m talking about.  The only difference is my likelihood of a seizure is probably 95+% less than others feeling this way only due to Cannabis. A partial onset or a brief stare off absence could happen and does with no notice of it by any other – the EEG still comes back negative.

A neurologist wants to do a 7 day study of me in the hospital and ‘turn his eye’ at the cannabis oils I use while hooked up to the machines. “Why would I possibly want to do that” I asked him in his office. His response “To see what happens, I’m curious and the insurance company approved it.” Wow, so the insurance company approved a $30,000 hospital stay but doesn’t pay for the medicinal cannabis I use that works.  This is the world we live in.  I denied his request to use me as a test tube rat and let him know I’ll continue to go with what causes that EEG to be negative!

Going through the last 5 years of doctors hasn’t been simple. Sometimes I’ve had to demand to either notate Cannabis Oils and CBD oils by milligrams per day as medicines on the list of medication – or I find another doctor and did over a half dozen times, hasn’t been simple. Intimidation is no longer an issue in doctor appointments most of the time – and that doesn’t bother me, it’s the mannerism of many physicians that do. We are people, not to be processed through a facility but to be cared for. Much of that has been lost in what was once doctors that practiced medicine and is now a medical industry. People are treated poorly because they choose to inhale Cannabis instead of ingest pills. The facts are simple, statistics are showing 25% on upwards of close to 50% of pain patients either moving over to cannabis in full or in a huge part. No longer wanting to consume Rx drugs that they know kill. I should know…  I am one of them.

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This is why when I discovered that both inhalation and ingestion was the key I went for it full force and have not stopped. Infusion of oils is very simple. Many people make Cannabis Budder (butter),  instead they could be using MCT coconut oil and keeping the temperature at or below 220 to not break the ‘chains’ of the Medium Chain Triglyceride Coconut oil. Of course many would argue they want their budder to make edibles with! So be it, I just made some myself!  Infusing Cannabis into natures oils has proven to be simple and super effective – especially using higher quality Cannabis material. MCT oil is a bit more temperamental than others but has so many health benefits. Olive oil is not so sensitive and various temperatures can be used to activate the plant.  I look at it simply.  I don’t want to have long term ingestion of any oil that could possibly have solvent in it,  but will do so short term as long as I have the labs that say it’s clean since It’s a Cancer battle along with Epilepsy once again.  So, to wrap this part up, fighting severe refractory generalized epilepsy with Cancer is very much different than fighting partial onset seizures or complex partials. Many aren’t aware that there are over 40 different types of seizures and countless types of Epilepsy diagnostics.  There’s 1/3rd of us roughly that don’t respond to medications, for me 27 different pharmaceuticals were tried over an 18 yr. period and when I started using oils I was on 12 medications/48 pills a day for Epilepsy.  That’s been narrowed down to one specific Rx for Epilepsy now with 4 tabs along with my various delivery methods of cannabinoids of all types.

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My motto?  Don’t discriminate against any one cannabinoid, it’s unfair as they all have functions far beyond knowledge already gained. We, the people with Epilepsy and other health issues, have lives that sometimes cause us to stay shut in.  Sensory overload, I compare it to what I’ve seen through the years with Autistic children, including my own. Having a neurological problem like this means that we have to watch for all kinds of things.  Being careful about that lighter flickering in the dark if I’m smoking a bong load is crucial to this day, I don’t know if it’s the anxiety or a tad of PTSD over being intubated and put into ICU over 3 dozen times due to status epilepticus that could not be stopped (non stop grand mal seizures that require the patient to be put into a drug induced very temporary coma generally with propofol).  Either way, our lives are effected in a brutal manner.  Many of my adult friends are a bit bewildered at the fact the FDA is about to approve a CBD only drug that supposed to be a natural extract but they will not be allowed to get it, even if they have a similar diagnosis as I do.

Limited FDA approvals for ‘cannabis drugs’ that are easily obtained throughout the US already seem a bit ridiculous. I feel bad for my friends in other states I can’t help due to strict laws. It’s a feeling inside that keeps a humble attitude intact. I hope, pray, and wish that every last person gets the ability to be nervous about seizures because they simply aren’t having them like they used to.  I hope that all of my friends suffer social anxiety standing in long lines waiting to take Amtrak trains across the country – alone!!! What I wish for? Independence for all – so what – we deal with anxiety like everyone else, it’s just new for us. It’s not different than anyone else in any other situation that now has freedom – it’s a whole new world so make the best of it.  Everyone is battling something,  always be mindful of this.

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That’s how I fight Epilepsy with Cannabis. I keep on persisting until I find ways to make the very best of what’s happening regardless of whatever obstacle or hurdle there is to leap over. I searched and finally found a doctor that would keep all records from all other doctors so I could document the last five years in a combined medical record. I found an expert in Cannabis right in my own town and eventually went to work to help the whole legitimization of our medication as a volunteer at first. We all must look to our doctors and ask them a simple question “Are you certified in Cannabinoid Medicine?” This should be our line of question and approach to a doctor vs “Is it okay for me to try CBD or Cannabis oil?”  I had to take control. Sure, this meant I lost some doctors at first but soon after I let them know up front and as well found a way to get the oils on my chart,  it became easy.  Nurses are always an excellent resource as they’ll ask you a valuable question ‘Have you started any new medications or changed any doses’?  What an excellent opening…

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This the time to state ‘yes, I’m using a CBD oil supplement at 50mg a day’.  Or whatever you may be doing – I used ‘I’m using CBD supplement at 100mg day and C.O. at 500mg’.  The Nurse writes it onto the medicine list in pen at that time then a receptionist or administrative assistant does the data entry.  One doctor questioned me about this 3 months after I first had it listed! Now that was an interesting conversation as she sat in there and vividly listened to how Cannabis oils had changed my life. If I had this link back then I would have shared it, I hope patients will encourage their doctors to learn. Here’s a link to the The American Academy of Cannabinoid Medicine that may help them learn.    http://www.aacmsite.org

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Doctors don’t have to be without knowledge and patients don’t have to feel like they’re under the gun when trying to talk to their physician about how to treat Epilepsy or any health condition with Cannabis.  Don’t expect a huge nod to go forward and a bunch of advice, you’d have to find one of the few specialists out there that knows this information – if your insurance covered it or if you could afford the visit.  This is why we all have to take our medical problems into our own hands as much as we possibly can. There are uses for western (modern) medicine and there are also disasters that can occur due to it in my opinion – especially when a patient starts to take pills due to side effects from pills. I’d rather take a different cannabinoid (CBD) to offset the feeling of others (THC,CBN) if necessary or combine them all and gain the very best medicine I can from the plant.

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Fighting Epilepsy with cannabis is always a unique battle. Keep that in mind when you see universal dosing and advice given. The same goes for almost every other medical problem cannabinoid medicine is used to treat. Always keep in mind the large number of types of diagnostics and types of seizure disorders – it’s just like cancer. There’s nearly 100 or more drugs for Epilepsy because of the vast spectrum of the diagnosis.



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Mike Robinson, Medicinal Cannabis Patient, Santa Barbara CA.

Founder, Global Cannabinoid Research Center, Cannabinoid Education for all 

Related comments

  • From trevmorones

    Your strength is admirable. Thank you for sharing, inspiring, and educating.

  • From Connor Christine

    Thank you for sharing. You are an inspiration.

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Prescription Drugs & Side Effects: Is It Worth The Risk?

We all know that pharmaceuticals can save lives, but we also know they kill. But exactly how many? The numbers are beyond shocking.

Reading Alex Steblowsky’s  Facbook post can be rather interesting – especially with my background in not only taking a plethora of prescription drugs and gaining multiple cancers thereafter, but in my research in regards to that being a large part of the reason why.  Let’s take a look at what Alex has to say…

“New Harvard study reveals institutional corruption of pharmaceuticals & how the FDA cannot be trusted with public safety.  According to Harvard report, in US alone, every week, 53,000 end up in hospitals & 2,400 die as a result of taking prescription drugs as prescribed.”
http://seattleorganicrestaurants.com/vegan-whole-food/institutional-corruption-of-pharmaceuticals-how-FDA-cannot-be-trusted-with-public-safety.php

Shocking to say the least! I can’t count the number of past and current Cannabis patients I know that have illnesses related to or directly from taking pharmaceuticals and now must take even more pharmaceuticals to offset reactions and side effects.. Many have turned to the beautiful cannabis plant for medicine instead – slowly working away from everything from pain medication to seizure medication for those that find control and help with cannabis vs. pharmaceuticals.
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Let’s learn more from Alex:
“Total corruption: Drug companies bought their way onto FDA advisory panels
It is now an undeniable fact that the pharmaceutical industry weaseled its way onto key U.S. Food and Drug Administration (FDA) advisory panels, which were instrumental in shaping the way drugs are safety tested and approved. According to The Washington Post (WP), a recent public records request has revealed that drug companies purchased special access onto these panels, where they were given the keys to the kingdom in swaying decision-makers about official drug policy.”
http://www.naturalnews.com/042562_total_corruption_drug_companies_FDA_advisory_panels.html

And by far it does not end with this…. Alex informs the public on a daily basis. It’s people like him that continue to walk their talk that change this world. Like the saying goes “I can’t help everybody, but everyone can help somebody”….

“The FDA continues to be one of the most dangerous government agencies in the United States. The sheer scope of people it affects with its corruption is staggering.  Constitutional Attorney on US Federal Drug Administration (FDA) Corruption, Disinformation and Cover Up of Health Dangers”
http://www.globalresearch.ca/constitutional-attorney-on-us-federal-drug-administration-fda-corruption-disinformation-and-cover-up-of-health-dangers/5430348

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We all know these drugs are dangerous. The FDA requires TV and Radio ad’s to blare out the side effects which are a very true reality for many.  Those that say these drugs are ‘safe’ obviously have not had permanent brain damage or died or they wouldn’t be able to make such a ridiculous statement in  this day and age of people that are now ‘awake’ about the dangers of Big Pharma and doctors that simply do not take the time to check contraindications – drugs that should not be taken together.  When a medicinal cannabis patient walks in the doors many times the physician will tell them they don’t know enough about the plant or there’s not enough research.  That same doctor that was trained in medicine for how many years…. fails to check and see if he or she has prescribed a medication that will mix poorly or interact with Cannabis. So why would a doctor make any statements about the pharmaceuticals being ‘safe’ when their actions as a doctor simply are not.  People die, it’s no joke and it’s people like Alex that are trying to educate the world.
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In a recent post Alex went on…

“It is steadily coming to light that we have for some time been the unwitting victims of a massive fraud by Big Pharma and psychiatry, the money-grubbing, brain-damaging Axis of Evil.

We have not just been sold snake oil or “miracle cures” by charlatans. We have been sold snake oil that not only doesn’t cure anything but also causes profound harm to anyone duped into consuming it.

Same thing with doctor’s, it’s all about the money not your health.”

Enough said, we know where Alex stands, and I am with him.
Visit his Facebook page at: https://www.facebook.com/asteblowsky?tn-str=*F

Thank you Alex for making my point even more clear about the Cannabis plant. It’s the reason why I’m alive and millions more. Mainstream medicine has plenty of room to integrate it into the use of other medications.  With Cannabis, as a researcher,  I’ve learned that we can utilize medications that exist in many different ways safely.  Many are simply unsafe and need to be removed and destroyed or put into schedule 1 where Cannabis should be taken out of it for obvious reasons. While the world revels at prescription CBD being made available soon, many in the know are aware it carries the same scary side effects and has killed already.

No drugs are free of side effect or completely safe… but we have alternatives that are pretty close, and in my opinion very perfect replacements.  Pretty ones too!
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Mike Robinson,  Medicinal Cannabis Patient,  Founder, The Global Cannabinoid Research Center

Related comments

Mike Robinson CBD and Wellness 1 month ago / Santa Barbara, Alberta


Research Shows Major Flaws In Epidiolex Pharmaceutical CBD

Key pharmacological differences between side effects of refined, pharmaceutical CBD formulations and whole plant extracts:

By: James Holley, Molecular Biologist, Scientific Officer, Mike Robinson, Co-founder, Research Institute, and Dr. David Ostrow, M.D., Research Director

International Cannabinoid Cancer Research Institute (Draft 5)

With review by:  (Pending) (This is not the Final Draft)

Abstract:  (This is not the final draft, the final is being submitted for Journal Publications)

Recent studies on the effectiveness of cannabidiol in the rare seizure disorders Dravet Syndrome and Lennox-Gastaut syndrome have prompted a biopharmaceutical company to perform clinical trials of its own to bring a cannabidiol based drug to the American market through the process of FDA approval. Side effects were very prevalent in 79% of all patients taking a refined CBD product, some of which were severe like thrombocytopenia and transaminase elevations in the liver. However, there are indications from studies done with cannabidiol-rich cannabis extracts in Israel that indicate that less side effects (46%) are achieved with a natural cannabis plant extract containing a 20:1 ratio of CBD to THC. This paper seeks to answer why refined cannabinoids have more side effects than the natural cannabis product, as well as the possible etiology of said adverse reactions. Also discussed are other attempts at affecting the cannabinoid system from a singular standpoint. Ultimately, the cannabinoid system works by way of multiple molecules affecting multiple receptors at once – the entourage effect, and thus such singular approaches to treatment by way of the cannabinoid system are not effective. Traditional plant extracts contain many compounds in addition to THC and CBD that contribute to the medical benefits of cannabis.

Introduction:

Recently, a formulation of cannabidiol was approved by the United States FDA. It is extracted from hemp grown using conventional agricultural methods like pesticides and fertilizers and extracted using supercritical carbon dioxide, crystallized, and put into a formulation with sesame oil, strawberry flavoring, alcohol, and sucralose, to be used alongside existing anti-seizure medications like clobazam. This differs sharply from the conventional course of cannabis medicine, which is to use whole, clean plant extracts to treat epilepsy and to gradually discontinue use of conventional pharmaceuticals. The question is, is there truly a difference? It might be argued by some that a compound is a compound, carbon for carbon, and thus it would have the same effects. However, it is sometimes the case that the pill binder or other carrier causes a medication issue. A review of the research must be done to find if natural plant extracts have an advantage over synthetic delivery systems.

Review:

During an open-label trial of pure CBD with Lennox-Gastaut and Dravet patients, 79% of all patients reported side effects. The most common side effects reported were somnolence (25%), decreased appetite (19%) diarrhea, (19%) Fatigue, (13%) Elevated liver enzymes, (7%) Convulsion, (11%) Increased appetite, (9%) Status epilepticus, (8%) Lethargy, (7%) Weight increased, (7%) Weight decreased, (6%) Drug concentration increased, (6%). Serious side effects in 30% of patients included status epilepticus in 6%, severe hepatotoxicity in 1 patient, and hyperammonemia in another. One patient died but it was ruled to be part of the course of their disorder and not a drug effect. The liver and urea cycle side effects were related to co-intake of valproate, the pre-existing medication. (1) The official FDA side effects include insomnia (11%) irritability (9%), a chance of suicidal ideation “common to anticonvulsants” and a 33% higher chance of infection. It makes no mention of any interaction with valproate (2) CBD was also found to increase the active metabolite of clobazam, a common medication for refractory epilepsy, by blocking cytochrome p450 enzymes CYP2c19 and 3A4. (3) All side effects were for a 70% overall seizure reduction and 52% reporting a decrease of 50% or more.

An Israeli study of cannabis versus epilepsy, however, used natural extracts with a ratio of 20:1 CBD:THC. When administered to children with epilepsy, seizure reduction occurred in 89% of patients and 54% achieved over 50% reduction. Only 7% had an increase in seizures, and only 7% had restlessness and irritability. 34/74 patients in all had side effects, or 46%. (4) Interestingly enough, Aran noted a similar prevalence of irritability and restlessness in the Israeli CBD trial for autism, further underlining the connections between autism and seizures. (5). In all of these trials, none of the patients were on other medications concurrently – it is common practice in cannabis medicine in both California and Israel to withdraw from other medication. No hepatic side effects were noted.

These two studies are not alone in their findings. A recent meta-analysis of CBD studies on Dravet, Lennox-Gastaut, and CDKL5, 5 of them using purified CBD and 6 of them using a CBD-rich extract, found more improvement in general with CBD-rich extracts. However, the number of patients experiencing a reduction of 50% or more held steady between the two groups at 39-42%. The CBD-rich extract group had a lower effective dose on average, 6.1 mg/kg while purified CBD required 27.1 mg/kg. Purified CBD also tripled the rate of both mild side effects such as appetite alteration, sleepiness, gastrointestinal disturbances/diarrhea, weight changes, fatigue, nausea, and severe side effects such as thrombocytopenia, respiratory infections, and alteration of liver enzymes. (6)

Discussion:

There are two possible explanations for the reduced side effect profile and increased efficacy of the whole plant extracts versus the refined CBD product now on the market. One of the main things that stands out is that in America, CBD was investigated as an adjunct to existing AEDs while in established cannabinoid medicine, patients are gradually withdrawn from existing drugs to use CBD. Drug interactions involving the liver are more common with multiple medications, and this is what was shown in the Lancet study. (1) Another is that the Israelis and others used whole plant extract with a small amount of THC in a 20:1 ratio. There is a phenomenon known as the “entourage effect” where the action of multiple cannabinoids and other plant compounds known as terpenes exhibit effects at a variety of receptors. This mimics what the endogenous cannabinoids do: they are synthesized at the same time in precise ratios, on demand, to exert precise effects on receptors. A neutral carrier made of sesame oil, strawberry flavoring, and sucralose has no synergy with CBD whatsoever. (7,8) Meanwhile, the terpene linalool has been shown to decrease glutamate binding and limonene and caryophyllene together have been shown to limit hippocampal excitability. (9,10)

Fig 1: Sucralose (In Study)

Fig 2: Ethyl Methylphenylglycidate (In Study)

Sucralose is common to use in a pediatric formulation. Although regarded as safe by the FDA, sucralose has since been find to alter glucose uptake and hormonal response to glucose, including of course insulin, and cause obesity in rats. (11) This effect is controversial in humans: some studies have shown no effect on glucose absorption in acute administration of sucralose in humans. (12) However, increased absorption of glucose was found, with corresponding increased insulin levels and decreased insulin sensitivity. (13) The strawberry flavoring ethyl methylphenylglycidate is another component with more questions than answers. It is registered as a pesticide ingredient with the EPA, and in the filing, LD50 numbers in rodents are noted and teratogenicity was noted in chickens. (14) NIH Toxnet cites studies that say that at 10000 ppm in rat feed caused growth retardation and testicular atrophy, while at 5000 ppm caused the demyelination of the sciatic nerve and can provoke hypersensitivity reactions with chronic exposure. (15) But more directly, there were two cases noted where strawberry flavoring caused reflex seizures with initial gamma band activity in the anterior inferior insula, with decreased activity in the hippocampus. (16) This is of interest because CB1 receptors are connected to gamma band activity and are most active in the hippocampus. (17,18) Meanwhile natural cannabinoids and terpenes are metabolized normally, with possible positive effects on blood sugar and metabolism and no added risk of seizures. (19)

Fig. 3. Synthesis of the synthetic cannabinoid JWH-018. (within study)

There have been other attempts to use a singular compound to affect the endocannabinoid system. For several years Dr. Piomelli at UC Irvine and his lab were involved in the development of FAAH inhibitors – substances that inhibited the breakdown of endocannabinoids. (20) The aim was to increase the level of 2-AG and anandamide in general so as to produce effective relief for a cannabinoid deficiency without any psychoactive side effects. Things seemed to go well in animal trials using URB597. (21) However, human trials of a similar compound BIA-10-2474 in France ended in disaster causing brain damage. (22) The problem in this case may have been off target inhibition of lipid metabolism in the brain, causing something similar to Tay-Sachs disease. (23) Piomelli predicted this might happen and he and other scientists disagree with how the French company went ahead with human trials. (24) Another famous attempt is the CB1 antagonist rimonabant – it was briefly tried as an appetite suppressant before it was found to cause anxiety, depression, and suicidal thoughts, causing Europe to ban the drug and major drug companies to stop researching the whole class of drug for human use. (25) Synthetic CB agonists, created to study the cannabinoid system, escaped the lab and became a whole new drug problem in the form of “Spice”. These chemicals have caused deaths and overdoses nationwide, causing New York to ban them on September 13, 2012 and the USA to follow suit, though new compounds are made every day. (26)

Fig. 4. THC

Another example of cannabinoid mono therapy is the THC pharmaceutical Marinol. After Professor Raphael Mechoulams discovery of THC as the main active principle in 1964, it took 22 more years for the FDA to approve its use as an appetite stimulant for AIDS and cancer patients, and only when all else had failed. (27) A 1998 study found a low potential for abuse and no indication of patients chasing the drug. (28) Side effects noted included strangely enough, vomiting and abdominal pain, psychiatric side effects including depression and paranoia, and low blood pressure. It has the same onset time of 60-90 min as cannabis edibles but only lasts 2-4 hours: many patients report edible cannabis made using the whole plant lasting 6-8 hours or more and find Marinol to be an inferior product (29,30). Concerns about mental and developmental health have been raised over THC and high THC cannabis concentrates, however CBD has been shown to moderate or even cancel out the effects of THC. (7). Hemp extracts are known to contain a small amount of THC even when derived from a CBD-rich cannabis cultivar and are known to produce positive test results for THC even in users of CBD hemp products. (31) The United States DEA has stated that small amounts of other cannabinoids will also occur in all cannabis extracts, even those that purport to be CBD only – unless synthesized de novo, CBD isolate will always contain small amounts of THC when extracted from a plant. Even chromatography is not perfect. If so, CBD medicines should warn of this at least for the purposes of drug testing. (32)

Fig. 5. CBD

But how exactly does CBD by itself produce adverse effects in a small percentage of seizure and autism patients when it is well tolerated by 90% of the patient population? Even whole plant extracts are not tolerated by this group. This is where emerging science may provide an answer. CBD is mostly antagonistic towards the CB1 and CB2 receptors, with a Ki of 3500-4000 nanomolar. (33) It has been found to be a negative allosteric modulator of both of them. (34, 35) It is also an antagonist at GPR55 and 18 which have been shown to be secondary cannabinoid receptors (36,37). THC, for example, is a full agonist at GPR18. (38). Mutations in MBOAT7, which produces the natural ligand lycophosphatidylinositol for GPR55, are linked to autism. (39) A duplication of the region containing GPR18 was linked to another case. (40) It is thus possible that autism and seizure cases exist where the proper rescue pathway is through stimulation of the GPR receptors and not via the multiple, mostly antagonistic actions that CBD is known for. CBD and other cannabinoids are also known for having a bell-shaped dose-response curve. In an experiment with mice using CBD-rich extract, the anti-inflammatory and pain relief effects peaked at only 5 mg/kg, which is close to the average dose found in CBD-rich extract studies. However, use of whole plant extract was able to overcome this and make the relationship correlative. It is possible that the dose used in studies using isolated CBD is too high in general and given the prospective study design in those studies versus the retrospective design used in the extract studies this remains a possibility. (41,6)

Conclusion:

Ultimately cannabinoid medicine must be based on a sound understanding of the underlying biological systems involved, as well as the unique human physiological response to inert synthetic ingredients that are proven herein to be the causation of most, if not all the side effects listed by the F.D.A. on the new pharmaceutical, and that the vast majority of these side effects are not from any extract of Cannabis, including CBD. As well, the conventional approach of isolating a single active principle and using it when prior study does not support such applications within the Endocannabinoid System, where multiple components are manufactured by the same enzymes in ratios to exert an effect in concert on the system in whole. More research is needed to determine proper ratios for specific conditions, as well as genetic testing developed to determine appropriate course of treatment. In all, neither CBD or THC alone are as opportune as a mono therapy without other accompanying elements of the plant including phytocannabinoids and terpenes. Efficacy in study is reduced when one cannabinoid is isolated away from the balance of the cannabis plant. The side effects stemming from the addition of synthetic inert ingredient to sweeten and flavor are found to be a risk of consideration for further study. When combined with other pharmaceutical medications, specifically seizure medications, the side effects are unnecessary and again, in a large part a cause of inert ingredients. In conclusion, the removal of Cannabidiol from its accompanying plant terpenes and other cannabinoids and it’s placement into a carrier consisting of sucralose, a synthetic strawberry flavoring, and sesame oil also reduces the effectiveness and heavily contributes to the F.D.A. listed common and severe side effects. There is no way to conclude that the new pharmaceutical compares to whole plant extract in any scientific way other than containing an isolated cannabinoid. Regarding the warning for specific populations that based on animal data the pharmaceutical may cause fetal harm. There is sufficient data, as indicated in discussion, that inert ingredients within this newly approved CBD pharmaceutical for the US Market have already been proven to cause harm in the unborn fetus, and not the cannabinoid. This would explain the special warning upon the current FDA approved drug. Moreover, since CBD can never be fully isolated, the packaging of CBD medicines should warn about the presence of THC.

References

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  • 38: Douglas McHugh1 , Jeremy Page1 , Emily Dunn1 and Heather B Bradshaw. D9 -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. British Journal of Pharmacology (2012) 165 2414–2424
  • 39. Anide Johansen,1,2 Rasim O. Rosti,1 Damir Musaev,1 Evan Sticca,3 Ricardo Harripaul,4 Maha Zaki,5 Ahmet Okay C¸ aglayan,6 Matloob Azam,7 Tipu Sultan,8 Tawfiq Froukh,9 Andre´ Reis,10 Bernt Popp,10 Iltaf Ahmed,11 Peter John,11 Muhammad Ayub,12 Tawfeg Ben-Omran,13,14 John B. Vincent,4 Joseph G. Gleeson,1,3,15,* and Rami Abou Jamra10,16. Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features. The American Journal of Human Genetics 99, 912–916, October 6, 2016.
  • 40. Atack a H. Fairtlough b K. Smith a M. Balasubramanian. A Novel (Paternally Inherited) Duplication 13q31.3q32.3 in a 12-Year-Old Patient with Facial Dysmorphism and Developmental Delay. Mol Syndromol 2014;5:245–250.
  • 41. Gallily, R., Yekhtin, Z. and Hanuš, L.O. (2015) Overcoming the Bell‐Shaped Dose‐Response of Can‐ nabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75‐85.

 

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A Note from Mike: As a patient with severe epilepsy and a father of not one but two children with it? I will let the research and study we have done speak for itself for the most part, but I’ll be backing it with public appearances and interviews to head off the ‘side effect’ warnings that we WILL SEE on TV and hear on the radio. This is serious – CBD is under attack and by the use of a very disturbing way of creating a product for children. The topic of inert ingredients in CBD products has been ongoing since inception of the many different types of oils we see on the market. Never have I personally witnessed anything quite like this. My opinion on this all will come in a future blog, at this time we’re doing initial publishing as there are multiple entities, mostly Epilepsy Societies and Foundations, that are awaiting this document for analysis and publication.

A good full extract CBD oil, which works well for many but not all, you will not find this on a pharmaceutical store shelf nor will you find via a prescription by your doctor who likely knows very little, if anything, about Cannabis or how to prescribe the new drug. Many are learning which is a great thing!

Full Spectrum CBD products of the best type, many times will come from the same type of Cannabis flower or bud that the THC crowd loves. Genetics have allowed Cannabis to advance quickly.

There’s simply no excuse for bastardizing the plant in a manner we see here in the extremely factual and well planned research study above. Over 50 well known researchers globally weighed in, and many with varying opinions. But the facts that James and I initiated seemed to be the ones that most are paying attention to. Inert ingredients coupled with a single cannabinoid delivery created through an odd lab process create a product that fails to meet efficacy standards and meets all non standards of causing side effects that include increased seizures. This makes no sense unless the plot in releasing this drug that will only serve 1/2 of 1% of the world of Epilepsy was to once again marginalize cannabis by using already marginalized people like myself – those with Epilepsy. Those the world writes off for the most part anyway.

The inert ingredients within the newly approved Pharmaceutical CBD are not only in a large way responsible for key very concerning side effects within it, but are known to promote seizures in a big way – proven with studies on the exact same flavoring. Why would a pharmaceutical company do this? But it gets worse, these are carcinogens, and are blatantly unsafe in my strong professional opinion.

The fact that this ‘CBD only’ pharmaceutical can cause a positive THC test per the DEA rule 7350 yet has NO WARNING? Now that seems beyond dangerous to consumers – it’s downright irresponsible on both the pharmaceutical companies behalf and the FDA/DEA combo who seem to not read each others inter office memos.

Thank you,

Mike Robinson, Medicinal Cannabis Patient and Founder, The Institute/Research Center

Related comments

  • From JADEO

    10% side-effects. That is a crazy high number. The larger concern, the public will not understand this product is not 'true plant-based' CBD and as a result lump the negative side-effects to the plant-based product. #Education

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